Promising New Treatments for Leukemia
Department of Medicine researchers have identified two new treatments for acute megakaryocytic leukemia (AMKL) in a study that was recently published in Cell. The senior author of the study is John Crispino, PhD, the Robert I. Lurie, MD, and Lora S. Lurie Professor of Medicine - Hematology/Oncology. The study found that a generic drug named alisertib significantly reduced the number of leukemia cells in mice. A multi-center clinical trial is being planned to begin in 2013, led by Jessica Altman, MD, Assistant Professor of Medicine - Hematology/Oncology.
The study also found that a chemical compound named dimethylfasudilcould also be effective against AMKL; although the alisertib treatment will be moving forward sooner.
The study was funded by the Samuel Waxman Cancer Research Foundation, Leukemia & Lymphoma Society, and National Cancer Institute. Read more on the study here.