Endocrinology, Metabolism, and Molecular Medicine Research & Studies
American Recovery and Reinvestment Act (ARRA) Grants
Dr. Andrea Dunaif Receives $2.3 million NIH ARRA Award
The National Institutes of Health has awarded Dr. Andrea Dunaif $2.3 million for her research project titled Genome Wide Association Study of Polycystic Ovary Syndrome. This is the largest American Recovery and Reinvestment Act (ARRA) funded grant received to date in the Department of Medicine. Margrit Urbanek, Ph.D. and Geoffrey Hayes, Ph.D. are co-investigators on this study.
The project will employ a genome wide association scan to identify PCOS susceptibility alleles in a cohort of ~1,200 PCOS cases and ~3,600 population-based female controls. The most promising variants will be further investigated using replication studies in an independent cohort of ~1,800 PCOS cases and ~5,400 population-based female controls. The identification of genetic determinants for PCOS will enhance the pathophysiologic understanding of the disease and may result in better disease prediction and prevention as well as more effective and specific treatments.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive age women, affecting 7% of this population. PCOS is a leading risk factor for Type 2 diabetes (T2D) in adolescent girls and young women and an important contributor to infertility, metabolic syndrome (MBS), T2D, and cardiovascular disease (CVD) risk factors in women.
Endocrinology and Women's Health
BIRCWH - Building Interdisciplinary Research Careers in Women's Health
SCOR - Specialized Center of Interdisciplinary Research on Sex and Gender Factors Affecting Women's Health
PCOS - Polycystic Ovarian Syndrome
Endocrinology Training Grant
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