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Past Research Areas (1995 - 2005)

The Peter Citation Classics

Research / References / Lab

Previous Accomplishments

In recent years apoptosis has emerged as an fundamental process important in tissue homeostasis, the
immune system (1) and during development. Countless diseases are characterized by dysregulation in
apoptosis (2,3). The Peter laboratory has been studying apoptosis signaling pathways. About 120
dedicated apoptosis inducing or signaling proteins are known. The main focus has been the function of the
members of the death effector domain (DED) proteins. The DED is a structural motif found in a number of
apoptosis signaling proteins many of which couple to the apoptosis inducing death receptors (4-7). The
best characterized member of this family of receptors is CD95 (APO-1/Fas) (4-6,8-15). Just like TNF-RI
and four other members of this family, TRAMP/Wsl/APO-3R/DR3/AIR, APO-2R/TRAIL-R/DR4, DR5/
TRICK2/TRAIL-R2, and DR6 CD95 carries an intracellular death domain (DD) by which it engages the
apoptosis machinery.

From 1995-2005 The Peter lab either identified or cloned and characterized the following DED containing
proteins:

  1. FADD - Identified in a complex of signaling proteins they called the death-inducing signaling complex (DISC) that forms at the activated CD95 receptor (15-19). They also demonstrated that FADD is selectively phosphorylated at serine 194 by a cell cycle specific kinase (20,21) that was identified as casein kinase Ia (22).
  2. Caspase-8 - Cloned as the main initiator caspase which is a part of the DISC and initiates the so called extrinsic apoptosis pathway (in collaboration with Matthias Mann and Vishva Dixit) (23,24).
  3. v-FLIP - Cloned and characterized this inhibitor of the DISC in collaboration with Juerg Tschopp (25).
  4. c-FLIP - Cloned this regulator of the activity of caspase-8 in the DISC. They showed in collaboration with Xiaolu Yang, that at low concentration c-FLIPL promotes activation of caspase-8 in the DISC (26) and at high concentrations it inhibits (27).
  5. DEDD - Cloned this highly conserved factor that acts both in nucleoli (involved in transcriptional regulation, 28,29) and in the cytosol, where it facilitates cleavage of intermediate filament proteins by
    caspase-3 (30,31). DEDD is a platform protein that is critical for assembly of effector molecules in the apoptosis pathway. Its activity is regulated by monoubiquitination (30-33).
  6. DEDD2 - Cloned this protein which is 48% identical to DEDD and acts together with DEDD on intermediate filaments (30).

Derived from these studies were a number of functional studies on pathways, their physiological roles in cells, tumors, organelles and their role in disease:

  1. Caspase-8 is activated at the DISC (34) through interdimer cleavage (35).
  2. One of caspase-8 main substrates is the cytolinker plectin (36).
  3. Certain cells the Peter lab called Type I cells execute the CD95 apoptosis program independently of mitochondria whereas others (Type II cells) require mitochondrial amplification (37-39). Therefore only
    Type II cells are rendered CD95 apoptosis resistant by overexpression/upregulation of Bcl-2 or Bcl-xL.
    Another feature of Type II cells is that they do not efficiently form a DISC (1,37,39,40).
  4. In apoptosis resistant peripheral T cells caspase-8 is not recruited to the DISC (27,41). Upon prolonged T cell activation these cells differentiated from a Bcl-xL protected Type II to a CD95 sensitive
    Type I phenotype (27).
  5. Bcl-xL acts downstream, of the DISC but upstream of mitochondria (42).
  6. Mitochondria of Bcl-xL protected cells the ability to sequester and inactivate active caspase-8 with the help of a mitochondrial protein BAR (43).
  7. In a model of streptozotocin-induced autoimmune diabetes the Peter group found that pancreatic islets taken from CD95 mutant mice (lpr mice) were resistant to autoimmune destruction when
    transplanted under kidney capsule of autoimmune mice whereas islets from wild-type mice were destroyed demonstrating a proapoptotic role of CD95 in type I diabetes (44).

 

References

1. Scaffidi, C., Kirchhoff, S., Krammer, P.H. and Peter, M.E. (1999) Apoptosis signaling in lymphocytes. Curr. Opin. Immunol., 11, 277-285.

2. Peter,M.E., Heufelder, A. and Hengartner, M.O (1997) Advances in apoptosis research. Proc. Natl. Acad. Sci. USA, 94, 12736-12737.

3. Peter,M.E., Ehret, A., Berndt., C. and Krammer, P.H. (1997) AIDS and the death receptors. British Medical Bulletin, 52, 604-616.

4. Peter,M.E., Scaffidi, C., Medema, J.P., Kischkel, F. and Krammer, P.H. (1998) "The Death Receptors", in Apoptosis: Biology and Mechanisms (ed. Kumar S.), Results and problems in cell differentiation vol. 23, Springer-Verlag, Heidelberg, pp. 25-63.

5. Schulze-Osthoff, K. Ferrari, D., Los, M., Wesselborg, S. and Peter, M.E. (1998) Apoptosis signaling by death receptors. Eur. J. Biochem., 254, 439-459.

6. Peter,M.E. and Krammer, P.H. (1998) Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis. Curr. Opin. Immunol., 10, 545-551.

7. Schulze-Osthoff, K. and Peter, M.E. (1999) The death receptors. In: Signaling pathways in Apoptosis. (Eds. M. Lavin, D. Watters); Series: Modern Genetics Vol. 5, Harwood Academic Publishers. pp31-54.

8. Krammer, P.H., Dhein, J., Walczak, H., Behrmann, I., Mariani, S., Matiba, B., Fath, M., Daniel, P.T., Knipping, E., Westendorp, M.O., Stricker, K., Bäumler, C., Hellbardt, S., Germer, M., Peter, M.E. and Debatin, K.-M. (1994) The role of APO-1-mediated apoptosis in the immune system. Immunol. Rev., 142, 175-191.

9. Peter,M.E., Westendorp, M.O., Walczak, H., Hellbardt, S., Knipping, E. and Krammer, P.H. (1995) APO-1-mediated apoptosis in the immune system. Futura, The Journal of the Boehringer Ingelheim Fond, 10, 21-26.

10. Peter,M.E. (1996) CD95-associating signaling molecules. in Symposium in Immunology VI: Tumor Immunology (Eds.: Eibl, Huber, Peter, Wahn), Springer, Heidelberg pp.49-56.

11. Walczak, H., Dhein, J., Peter,M.E. und Krammer, P.H. (1996) Activation-induced T cell death. Cell Death Differ., 3, 345.

12. Peter,M.E., Chinnayian, A., Hellbardt, S., Kischkel, F., Krammer, P.H. and Dixit, V.M. (1996) The CD95 (APO-1/Fas) associating signaling molecules. Cell Death Differ., 3, 161-170.

13. Peter,M.E., Ehret, A., Berndt., C. and Krammer, P.H. (1997) AIDS and the death receptors. British Medical Bulletin, 52, 604-616.

14. Peter,M.E., Barnhart, B.C. and Algeciras-Schimnich, A. (2003) FasL/CD95L and its receptor CD95 (APO-1/Fas). in "Cytokine Handbook", 4th Edition. Ed. A. Thomson, M. Lotze. Academic Press. Vol.2, pp. 885-911.

15. Peter,M.E. and Krammer, P.H. (2003) The CD95 death-inducing signaling complex and beyond. Cell Death Differ., 10, 26-35.

16. Kischkel, F.C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P.H. and Peter, M.E. (1995) Cytotoxicity-dependent APO-1(Fas/CD95)-associated proteins form a death-inducing signalling complex (DISC) with the receptor. EMBO J., 14, 5579- 5588. Minireview in Cell: Ihle and Cleveland. (1995) Contenders in FasL/TNF signaling. Cell 81:479.

17. Chinnaiyan, A.M., Tepper, C., Lou, L., O'Rourke, K., Seldin, M.A., Kischkel, F., Hellbardt, S., Krammer, P. H., Peter, M.E. and Dixit, V M. (1996) FADD/MORT1 is a common mediator of Fas/APO-1- and tumor necrosis factor-induced apoptosis. J. Biol. Chem., 271, 4961-4965.

18. Scaffidi, C., Kischkel, F.C, Krammer P.H. and Peter, M.E. (1999) Isolation and analysis of the CD95 (APO-1/Fas) death-inducing signaling complex (DISC). Methods, a companion to Methods in Enzymology, 17, 287-291.

19. Scaffidi, C., Krammer, P.H. and Peter, M.E. (2000) Analysis of the CD95 (APO-1/Fas) death-inducing signaling complex (DISC) by high resolution IEF/SDS-PAGE 2D gels. Methods in Enzymol., 322, 363-373.

20. Scaffidi, C., Volkland, J., Blomberg, I, Hoffmann, I., Krammer, P.H. and Peter, M.E. (2000) Phosphorylation of FADD/Mort1 at serine 194 and association with a 70 kDa cell cycle regulated kinase. J. Immunol., 164, 1236-1242.

21. Alappat, E.C., Volkland, J. and Peter, M.E. (2003) Growth inhibition by C-FADD depends on its C-terminal phosphorylation site. J. Biol. Chem., 278, 41585-41588, (accelerated publication).

22. Alappat, E.C., Feig, C., Boyerinas, B., Volkland, J., Samuels, M., Murmann, A.E., Thorburn, A., Kidd, V.J., Slaughter, C.A., Osborn, S., Winoto, A., Tang, W.-J. and Peter, M.E. (2005) Phosphorylation of FADD at serine 194 by CKIa regulates its nonapoptotic activities. Mol. Cell, 19, 321-332.

23. Muzio, M., Chinnaiyan, A.M., Kischkel, F.C., O' Rourke, K., Shevchenko, A., Scaffidi, C., Zhang, M., Ni, J., Gentz, R., Mann, M., Krammer, P.H., Peter, M.E.* and Dixit, V.M. * (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex (DISC), Cell, 85, 817-827. *shared senior authorship. Voted by "Science" to be one of the top 10 discoveries of 1996. 3rd most cited paper in 1997.

24. Scaffidi, C., Medema, J.P., Krammer, P.H. and Peter, M.E. (1997) FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. J. Biol. Chem., 272, 26953-26958.

25. Thome, M., Schneider, P., Hofmann, K., Burns, K., Mattmann, C., Bodmer, J.-L., Schröter, M., Neipel, F., Scaffidi, C., Krammer, P.H., Peter, M.E. and Tschopp, J. (1997) Viral FLICE-inhibitory proteins (FLIPS) prevent apoptosis induced by death receptors, Nature, 386, 517-521.

26. Chang, D.W., Xing,, Z., Pan, Y., Algeciras-Schimnich, A., Barnhart, B.C.,Yaish-Ohad, S., Peter, M. E. and Yang, X. (2002) c-FLIPL is a dual function regulator for caspase-8 activation and CD95 (APO-1/Fas-mediated apoptosis. EMBO J., 21: 3704-3714.

27. Scaffidi, C., Schmitz, I., Krammer, P.H. and Peter, M.E. (1999) Role of c-FLIP in modulation of CD95-induced apoptosis, J. Biol. Chem., 274, 1541-1548.

28. Stegh, A.H., Schickling, O., Ehret, A., Scaffidi, C., Peterhänsel, C., Längst, G., Hoffmann, T., Grummt, I., Krammer, P.H. and Peter, M.E. (1998) DEDD, a novel death effector containing apoptosis-inducing protein targeted to nucleoli. EMBO J., 17, 5974-5986.

29. Schickling, O., Stegh, A.H., Byrd, J. and Peter, M.E. (2001) Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ., 8, 1157-1168.

30. Lee, J.C., Schickling, O., Stegh, A.H., Oshima, R., Dingsdale, D., Cohen, G.M. and Peter, M.E. (2002) DEDD regulates degradation of intermediate filaments during apoptosis. J. Cell Biol., 158, 1051-1066.
Highlighted in the same issue of JCB: "DEDD spells death to caspase substrates".

31. Dinsdale D., Lee J.C., Dewson G., Cohen, G.M. and Peter M.E. (2004) Intermediate filaments control the intracellular distribution of caspases during apoptosis. Am. J. Pathol., 164, 395-407.

32. Lee, J.C. and Peter, M.E. (2003) Regulation of apoptosis by ubiquitination. Immunol. Rev., 193, 39-47.

33. Lee, K.-H., Feig, C., Tchikov, V., Schickel, R., Hallas, C., Schuetze, S., Peter, M.E.* and Chan, A.C.* (2006) The role of receptor internalization in CD95 signaling. EMBO J., 25, 1009-1023. * shared senior authorship.Highlighted in Nature Immunol. 7, 373 (2006) as "CD95 internalization".

34. Medema, J.P., Scaffidi, C., Kischkel, F.C., Shevchenko, A., Mann, M., Krammer, P.H. and Peter, M.E. (1997) FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J., 16, 2794-2804.

35. Chang, D.W., Xing, Z., Capacio, V, Peter, M.E. and Yang, X. (2003) Interdimer processing mechanism of procaspase-8 activation. EMBO J., 22, 4132-4142.

36. Stegh, A.H., Herrmann, H., Lampel, S., Weisenberger, D., Andrä, K., Seper, M., Wiche, G., Krammer, P.H. and Peter, M.E. (2000) Identification of the cytolinker plectin as a major early in vivo substrate for caspase-8 during CD95 and TNF-receptor mediated apoptosis. Mol. Cell. Biol., 20, 5665-5679.

37. Scaffidi, C., Fulda, S., Srinivasan, A., Li, Feng, Friesen, C., Tomasseli, K.J.., Debatin, K.-M., Krammer, P.H. and Peter, M.E. (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J., 17, 1675-1687. Highlighted in The Scientist as one of the hot papers of 1998: "Deconstructing Tumor Necrosis Factor". (2000) The Scientist 14:19.

38. Scaffidi, C., Schmitz, I., Zha, J., Korsmeyer, S.J., Krammer, P.H., Peter, M.E. (1999) Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J. Biol. Chem., 274, 22532-22538.

39. Barnhart B.C., Alappat, E., and Peter, M.E. (2003) The CD95 Type I/Type II model. Sem. Immunol. 15, 185-193.

40. Algeciras-Schimnich, A., Pietras, E., Barnhart, B.C., Legembre, P., Vijayan, S., Holbeck, S.L. and Peter, M.E. (2003) Two CD95 tumor classes with different sensitivites to antitumor drugs. Proc. Natl. Acad. Sci. USA, 100, 11445-11450.

41. Peter, M.E., Kischkel, F.C., Scheuerpflug, C., Medema, J.P., Debatin, K.-M. and Krammer, P.H. (1997). Resistance of cultured peripheral T cells towards activation induced cell death involves a lack of recruitment of FLICE to the death-inducing signaling complex (DISC). Eur. J. Immunol., 27, 1207-1212.

42. Medema, J.P., Scaffidi, C., Krammer, P.H. and Peter, M.E. (1998) Bcl-xL acts downstream of caspase-8 activation by the death-inducing signaling complex, J. Biol. Chem., 273, 3388-3393.

43. Stegh, A.H., Barnhart, B.C., Volkland, J, Algeciras-Schimnich, A, Ke N., Reed, J. and Peter,M.E. (2002) Inactivation of caspase-8 on mitochondria of Bcl-xL expressing MCF7-Fas cells: Role for the BAR protein. J. Biol. Chem., 277, 4351-4360.

44. Vijayan, S., Zhou, P., Rajapaksha, T.W., Alegre, M.L. and Peter,M.E. (2005) Transplanted islets from lpr mice are resistant to autoimmune destruction in a model of streptozotocin-induced type I diabetes. Apoptosis, 10, 725-730. Highlighted in "Diabetes Week" 10/26/05.

 

The Peter Citation Classics

 

Dr. Peter has over the years produced a number of citation classics.
a) “summa classics” are cited more than 300 times; b) “mega classics” cited at least 150 times; and c) “classics” are cited at least 75 times.
   

Citations are as of July 27, 2010 (citations shown in bold denote first, co-first, senior or co-senior authorship).
Total number of citations: 15,426. Average number of citations/publication: 113.87 (total: 135 indexed publications). h-index = 51.
 
c) "Summa classics"
 
1. Muzio M, Chinnaiyan AM, Kischkel FC, et al.
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
CELL 85 (6): 817-827 JUN 14 1996
Times Cited: 2283
 
2. Scaffidi C, Fulda S, Srinivasan A, et al.
Two CD95 (APO-1/Fas) signaling pathways
EMBO J 17 (6): 1675-1687 MAR 16 1998
Times Cited: 1868
 
3. Kischkel FC, Hellbardt S, Behrmann I, et al.
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
EMBO J 14 (22): 5579-5588 NOV 15 1995
Times Cited: 1069
 
4. Medema JP, Scaffidi C, Kischkel FC, et al.
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
EMBO J 16 (10): 2794-2804 MAY 15 1997
Times Cited: 837
 
5. Thome M, Schneider P, Hofmann K, et al.
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors 
NATURE 386 (6624): 517-521 APR 3 1997
Times Cited: 620
 
6. Chinnaiyan AM, Tepper CG, Seldin MF, et al.
FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
J BIOL CHEM 271 (9): 4961-4965 MAR 1 1996
Times Cited: 611
 
7. Schulze-Osthoff K, Ferrari D, Los M, et al.
Apoptosis signaling by death receptors
EUROPEAN JOURNAL OF BIOCHEMISTRY 254 (3): 439-459 JUN 15 1998
Times Cited: 590
 
8. Scaffidi C, Schmitz I, Krammer PH, et al.
The role of c-FLIP in modulation of CD95-induced apoptosis
JOURNAL OF BIOLOGICAL CHEMISTRY 274 (3): 1541-1548 JAN 15 1999
Times Cited: 457
 
9. Peter ME, Krammer PH
The CD95(APO-1/Fas) DISC and beyond
CELL DEATH AND DIFFERENTIATION 10 (1): 26-35 JAN 2003
Times Cited: 426
 
10. Scaffidi C, Schmitz I, Zha JP, et al.
Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
JOURNAL OF BIOLOGICAL CHEMISTRY 274 (32): 22532-22538 AUG 6 1999
Times Cited: 403
 
11. Peter ME, Krammer PH
Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis
CURRENT OPINION IN IMMUNOLOGY 10 (5): 545-551 OCT 1998
Times Cited: 320
 
b) "mega classics"
 
12. Scaffidi C, Medema JP, Krammer PH, et al.
FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b
JOURNAL OF BIOLOGICAL CHEMISTRY 272 (43): 26953-26958 OCT 24 1997
Times Cited: 290
 
13. Chang DW, Xing Z, Pan Y, et al.
c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
EMBO JOURNAL 21 (14): 3704-3714 JUL 15 2002
Times Cited: 232
 
14. Krammer PH, Dhein J, Walczak H, et al.
THE ROLE OF APO-1-MEDIATED APOPTOSIS IN THE IMMUNE-SYSTEM
IMMUNOLOGICAL REVIEWS 142: 175-191 DEC 1994
Times Cited: 223
 
15. Algeciras-Schimnich A, Shen L, Barnhart BC, et al.
Molecular ordering of the initial signaling events of CD95.
MOL CELL BIOL. 2002 JAN;22(1):207-20.
Times Cited: 192
 
16. Kroemer G, El-Deiry W, Golstein P, et al.
CELL DEATH AND DIFFERENTIATION 12: 1463-1467
Times Cited: 191
 
17. Fulda S, Scaffidi C, Susin SA, et al.
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
JOURNAL OF BIOLOGICAL CHEMISTRY 273 (51): 33942-33948 DEC 18 1998
Times Cited: 185
 
18. Fulda S, Friesen C, Los M, et al.
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
CANCER RESEARCH 57 (21): 4956-4964 NOV 1 1997
Times Cited: 184
 
19. Barnhart BC, Alappat EC, Peter ME
The CD95 type I/type II model
SEMINARS IN IMMUNOLOGY 15 (3): 185-193 JUN 2003
Times Cited: 174
 
a) "classics"
 
20. Kroemer G, Galluzzi L, Vandenabeele P, et al.
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
CELL DEATH AND DIFFERENTIATION 16 (1): 3-11 JAN 2009
Times cited: 149
 
21. Peter ME, Kischkel FC, Scheuerpflug CG, et al.
Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex
EUROPEAN JOURNAL OF IMMUNOLOGY 27 (5): 1207-1212 MAR 1997
Times Cited: 145
 
22. Scaffidi C, Kirchhoff S, Krammer PH, et al.
Apoptosis signaling in lymphocytes
CURRENT OPINION IN IMMUNOLOGY 11 (3): 277-285 JUN 1999
Times Cited: 139
  
23. Park SM, Gaur AB, Lengyel E, et al.
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.
GENES & DEVELOPMENT 22(7) 894-907 APR 1 2008
Times cited: 130
 
24. Cahill MA, Peter ME, Kischkel FC, et al.
CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases
ONCOGENE 13 (10): 2087-2096 NOV 21 1996
Times Cited: 119
 
25. Peter ME, Heufelder AE, Hengartner MO
Advances in apoptosis research
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94 (24): 12736-12737 NOV 25 1997
Times Cited: 117
 
26. Martin DA, Zheng LX, Siegel RM, et al.
Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96 (8): 4552-4557 APR 13 1999
Times Cited: 109
 
27. Exley M, Varticovski L, Peter M, et al.
Association of phosphatidylinositol 3-kinase with a specific sequence of the T-cell receptor XI-chain is dependent on T-cell activation
JOURNAL OF BIOLOGICAL CHEMISTRY 269(21): 15140-15146  MAY 27 1994
Times Cited: 108
 
28. Fulda S, Scaffidi C, Pietsch T, et al.
Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells
CELL DEATH AND DIFFERENTIATION 5 (10): 884-893 OCT 1998
Times Cited: 96
 
29. Stegh AH, Herrmann H, Lampel S, et al.
MOLECULAR AND CELLULAR BIOLOGY 20(15): 5665-5679
Times Cited: 94
 
30. Willems F, Amraoui Z, Vanderheyde N, et al.
Expression of c-FLIPL and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide
BLOOD 95 (11): 3478-3482 JUN 1 2000
Times Cited: 90
 
31. Stegh AH, Schickling O, Ehret A, et al.
DEDD, a novel death effector domain-containing protein, targeted to the nucleolus
EMBO JOURNAL 17 (20): 5974-5986 OCT 15 1998
Times Cited: 88
 
32. Lee KH, Feig C, Tchikov V, et al.
The role of receptor internalization in CD95 signaling
EMBO JOURNAL 25(5): 1009-1023 MAR 8 2006
Times Cited: 87
 
33. Scaffidi C, Volkland J, Blomberg I, et al.
Phosphorylation of FADD/MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase
JOURNAL OF IMMUNOLOGY 164(3): 1236-1242 FEB 1 2000
Times Cited: 85
 
34. Medema JP, Scaffidi C, Krammer PH, et al.
Bcl-x(L) acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex
JOURNAL OF BIOLOGICAL CHEMISTRY 273 (6): 3388-3393 FEB 6 1998
Times Cited: 83
 
35. Medema JP, Toes REM, Scaffidi C, et al.
Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis
EUROPEAN JOURNAL OF IMMUNOLOGY 27(12): 3492-3498
Times Cited: 81
 
36. Peter ME, Kischkel FC, Hellbardt S, et al.
CD95 (APO-1/Fas)-associating signalling proteins
CELL DEATH AND DIFFERENTIATION 3 (2): 161-170 APR 1996
Times Cited: 79
 
37. Barnhart BC, Legembre P, Pietras E, et al.
CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells
EMBO JOURNAL 23(15): 3175-3185 AUG 4 2004
Times Cited: 75
 
38. Let-7 expression defines two differentiation stages of cancer
Shell S, Park SM, Radiabi AR, et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104 (27): 11400-11405 JUL 3 2007