Recent Publications
G.R. Scott Budinger, MD
Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.
Duch MC, Budinger GR, Liang YT, Soberanes S, Urich D, Chiarella SE, Campochiaro LA, Gonzalez A, Chandel NS, Hersam MC, Mutlu GM
Nano letters 2011 Dec 14; 11(12):5201-7
PMID: 22023654
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-{beta}1 signalling.
Mutlu GM, Budinger GR, Wu M, Lam AP, Zirk A, Rivera S, Urich D, Chiarella SE, Go LH, Ghosh AK, Selman M, Pardo A, Varga J, Kamp DW, Chandel NS, Sznajder JI, Jain M
Thorax 2011 Sep 15; :
PMID: 21921091
Angiotensin II and pulmonary fibrosis, a new twist on an old story.
Budinger GR
American journal of physiology. Lung cellular and molecular physiology 2011 Sep; 301(3):L267-8
PMID: 21724862
Update in environmental and occupational medicine 2010.
Budinger GR, Mutlu GM
American journal of respiratory and critical care medicine 2011 Jun 15; 183(12):1614-9
PMID: 21693716
Nuclear {beta}-catenin is Increased in SSc Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation.
Lam AP, Flozak AS, Russell S, Wei J, Jain M, Mutlu GM, Budinger GR, Feghali-Bostwick CA, Varga J, Gottardi CJ
American journal of respiratory cell and molecular biology 2011 Apr 14; :
PMID: 21454805
A dystroglycan/plectin scaffold mediates mechanical pathway bifurcation in lung epithelial cells.
Takawira D, Budinger GR, Hopkinson SB, Jones JC
The Journal of biological chemistry 2011 Feb 25; 286(8):6301-10
PMID: 21149456
Leptin Promotes Fibroproliferative ARDS by Inhibiting Peroxisome Proliferator-activated Receptor-{gamma}
Jain M, Budinger GS, Lo A, Urich D, Rivera SE, Ghosh AK, Gonzalez A, Chiarella SE, Marks K, Donnelly HK, Soberanes S, Varga J, Radigan KA, Chandel NS, Mutlu GM
American journal of respiratory and critical care medicine 2011 Feb 11; :
PMID: 21317313
Particulate Matter-Induced Lung Inflammation Increases Systemic Levels of PAI-1 and Activates Coagulation Through Distinct Mechanisms.
Budinger GR, McKell JL, Urich D, Foiles N, Weiss I, Chiarella SE, Gonzalez A, Soberanes S, Ghio AJ, Nigdelioglu R, Mutlu EA, Radigan KA, Green D, Kwaan HC, Mutlu GM
PloS one 2011; 6(4):e18525
PMID: 21494547
Epithelial Cell Death is an Important Contributor to Oxidant-Mediated Acute Lung Injury.
Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS
American journal of respiratory and critical care medicine 2010 Oct 19; :
PMID: 20959557
Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity.
Mutlu GM, Budinger GR, Green AA, Urich D, Soberanes S, Chiarella SE, Alheid GF, McCrimmon DR, Szleifer I, Hersam MC
Nano letters 2010 May 12; 10(5):1664-70
PMID: 20377197
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS
Proceedings of the National Academy of Sciences of the United States of America 2010 May 11; 107(19):8788-93
PMID: 20421486
Proteasomal regulation of pulmonary fibrosis.
Weiss CH, Budinger GR, Mutlu GM, Jain M
Proceedings of the American Thoracic Society 2010 Feb; 7(1):77-83
PMID: 20160152
{beta}-catenin/TCF signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.
Flozak AS, Lam AP, Russell S, Jain M, Peled ON, Sheppard KA, Beri R, Mutlu GM, Budinger GS, Gottardi CJ
The Journal of biological chemistry 2009 Nov 20; :
PMID: 19933277
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.
Urich D, Soberanes S, Burgess Z, Chiarella SE, Ghio AJ, Ridge KM, Kamp DW, Chandel NS, Mutlu GM, Budinger GR
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Jul; 23(7):2055-64
PMID: 19237507
Role of mitochondrial hOgg1 and aconitase in oxidant-induced lung epithelial cell apoptosis.
Panduri V, Liu G, Surapureddi S, Kondapalli J, Soberanes S, de Souza-Pinto NC, Bohr VA, Budinger GR, Schumacker PT, Weitzman SA, Kamp DW
Free radical biology & medicine 2009 Jun 11; :
PMID: 19524665
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.
Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, Budinger GR, Chandel NS
Free radical biology & medicine 2009 May 15; 46(10):1386-91
PMID: 19268526
Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways.
Chandel NS, Budinger GR, Mutlu GM, Varga J, Synenki L, Donnelly HK, Zirk A, Eisenbart J, Jovanovic B, Jain M
Critical care medicine 2009 May; 37(5):1678-84
PMID: 19325470
Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.
Klimova TA, Bell EL, Shroff EH, Weinberg FD, Snyder CM, Dimri GP, Schumacker PT, Budinger GR, Chandel NS
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Mar; 23(3):783-94
PMID: 18948382
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR
The Journal of biological chemistry 2009 Jan 23; 284(4):2176-86
PMID: 19033436
BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK.
Shroff EH, Snyder CM, Budinger GR, Jain M, Chew TL, Khuon S, Perlman H, Chandel NS
PloS one 2009; 4(5):e5646
PMID: 19468307
Tubulin acetylation and histone deacetylase 6 activity in the lung under cyclic load.
Geiger RC, Kaufman CD, Lam AP, Budinger GR, Dean DA
American journal of respiratory cell and molecular biology 2009 Jan; 40(1):76-82
PMID: 18635817
Stretch-induced activation of AMP kinase in the lung requires dystroglycan.
Budinger GR, Urich D, DeBiase PJ, Chiarella SE, Burgess ZO, Baker CM, Soberanes S, Mutlu GM, Jones JC
American journal of respiratory cell and molecular biology 2008 Dec; 39(6):666-72
PMID: 18556591
Navdeep Chandel, PhD
Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.
Duch MC, Budinger GR, Liang YT, Soberanes S, Urich D, Chiarella SE, Campochiaro LA, Gonzalez A, Chandel NS, Hersam MC, Mutlu GM
Nano letters 2011 Dec 14; 11(12):5201-7
PMID: 22023654
Seeing the Light: Probing ROS In Vivo Using Redox GFP.
Tormos KV, Chandel NS
Cell metabolism 2011 Dec 7; 14(6):720-1
PMID: 22152299
Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation.
Vohwinkel CU, Lecuona E, Sun H, Sommer N, Vadász I, Chandel NS, Sznajder JI
The Journal of biological chemistry 2011 Oct 28; 286(43):37067-76
PMID: 21903582
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-{beta}1 signalling.
Mutlu GM, Budinger GR, Wu M, Lam AP, Zirk A, Rivera S, Urich D, Chiarella SE, Go LH, Ghosh AK, Selman M, Pardo A, Varga J, Kamp DW, Chandel NS, Sznajder JI, Jain M
Thorax 2011 Sep 15; :
PMID: 21921091
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.
Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI
Molecular and cellular biology 2011 Sep; 31(17):3546-56
PMID: 21730292
p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis.
Dirisina R, Katzman RB, Goretsky T, Managlia E, Mittal N, Williams DB, Qiu W, Yu J, Chandel NS, Zhang L, Barrett TA
Gastroenterology 2011 Sep; 141(3):1036-45
PMID: 21699775
Leptin Promotes Fibroproliferative ARDS by Inhibiting Peroxisome Proliferator-activated Receptor-{gamma}
Jain M, Budinger GS, Lo A, Urich D, Rivera SE, Ghosh AK, Gonzalez A, Chiarella SE, Marks K, Donnelly HK, Soberanes S, Varga J, Radigan KA, Chandel NS, Mutlu GM
American journal of respiratory and critical care medicine 2011 Feb 11; :
PMID: 21317313
Mitochondrial complex III: an essential component of universal oxygen sensing machinery?
Chandel NS
Respiratory physiology & neurobiology 2010 Dec 31; 174(3):175-81
PMID: 20708106
Epithelial Cell Death is an Important Contributor to Oxidant-Mediated Acute Lung Injury.
Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS
American journal of respiratory and critical care medicine 2010 Oct 19; :
PMID: 20959557
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes.
Hamanaka RB, Chandel NS
Trends in biochemical sciences 2010 Sep; 35(9):505-13
PMID: 20430626
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS
Proceedings of the National Academy of Sciences of the United States of America 2010 May 11; 107(19):8788-93
PMID: 20421486
Inter-connection between mitochondria and HIFs.
Tormos KV, Chandel NS
Journal of cellular and molecular medicine 2010 Apr; 14(4):795-804
PMID: 20158574
Mitochondrial regulation of oxygen sensing.
Chandel NS
Advances in experimental medicine and biology 2010; 661:339-54
PMID: 20204741
Mitochondrial reactive oxygen species regulate hypoxic signaling.
Hamanaka RB, Chandel NS
Current opinion in cell biology 2009 Dec; 21(6):894-9
PMID: 19781926
Reactive oxygen species-dependent signaling regulates cancer.
Weinberg F, Chandel NS
Cellular and molecular life sciences : CMLS 2009 Dec; 66(23):3663-73
PMID: 19629388
Mitochondrial reactive oxygen species are required for hypoxia-induced degradation of keratin intermediate filaments.
Na N, Chandel NS, Litvan J, Ridge KM
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Nov 6; :
PMID: 19897662
Mitochondrial regulation of cell survival and death during low-oxygen conditions.
Snyder CM, Chandel NS
Antioxidants & redox signaling 2009 Nov; 11(11):2673-83
PMID: 19580395
Mitochondrial metabolism and cancer.
Weinberg F, Chandel NS
Annals of the New York Academy of Sciences 2009 Oct; 1177:66-73
PMID: 19845608
Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.
Gusarova GA, Dada LA, Kelly AM, Brodie C, Witters LA, Chandel NS, Sznajder JI
Molecular and cellular biology 2009 Jul; 29(13):3455-64
PMID: 19380482
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.
Urich D, Soberanes S, Burgess Z, Chiarella SE, Ghio AJ, Ridge KM, Kamp DW, Chandel NS, Mutlu GM, Budinger GR
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Jul; 23(7):2055-64
PMID: 19237507
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.
Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, Budinger GR, Chandel NS
Free radical biology & medicine 2009 May 15; 46(10):1386-91
PMID: 19268526
Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways.
Chandel NS, Budinger GR, Mutlu GM, Varga J, Synenki L, Donnelly HK, Zirk A, Eisenbart J, Jovanovic B, Jain M
Critical care medicine 2009 May; 37(5):1678-84
PMID: 19325470
Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.
Klimova TA, Bell EL, Shroff EH, Weinberg FD, Snyder CM, Dimri GP, Schumacker PT, Budinger GR, Chandel NS
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Mar; 23(3):783-94
PMID: 18948382
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR
The Journal of biological chemistry 2009 Jan 23; 284(4):2176-86
PMID: 19033436
BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK.
Shroff EH, Snyder CM, Budinger GR, Jain M, Chew TL, Khuon S, Perlman H, Chandel NS
PloS one 2009; 4(5):e5646
PMID: 19468307
Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members.
Snyder CM, Shroff EH, Liu J, Chandel NS
PloS one 2009; 4(9):e7059
PMID: 19768117
Mitochondrial complex III regulates hypoxic activation of HIF.
Klimova T, Chandel NS
Cell death and differentiation 2008 Apr; 15(4):660-6
PMID: 18219320
Hypoxia-inducible factor: roles in development, physiology, and disease.
Chandel NS, Simon MC
Cell death and differentiation 2008 Apr; 15(4):619-20
PMID: 18345017
Targeting the mitochondria for cancer therapy: regulation of hypoxia-inducible factor by mitochondria.
Bell EL, Klimova T, Chandel NS
Antioxidants & redox signaling 2008 Mar; 10(3):635-40
PMID: 17999628
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
Emerling BM, Weinberg F, Liu JL, Mak TW, Chandel NS
Proceedings of the National Academy of Sciences of the United States of America 2008 Feb 19; 105(7):2622-7
PMID: 18268343
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.
Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI
The Journal of clinical investigation 2008 Feb; 118(2):752-62
PMID: 18188452
A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation.
Lin X, David CA, Donnelly JB, Michaelides M, Chandel NS, Huang X, Warrior U, Weinberg F, Tormos KV, Fesik SW, Shen Y
Proceedings of the National Academy of Sciences of the United States of America 2008 Jan 8; 105(1):174-9
PMID: 18172210
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.
Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT
Molecular and cellular biology 2008 Jan; 28(2):718-31
PMID: 17967865
Thomas C. Corbridge, MD
Use of simulation-based education to improve resident learning and patient care in the medical intensive care unit: A randomized trial.
Schroedl CJ, Corbridge TC, Cohen ER, Fakhran SS, Schimmel D, McGaghie WC, Wayne DB
Journal of critical care 2011 Oct 25; :
PMID: 22033049
Pressure modes of invasive mechanical ventilation.
Singer BD, Corbridge TC
Southern medical journal 2011 Oct; 104(10):701-9
PMID: 21941160
Teratoma of the ovary with sarcomatous transformation and pulmonary metastases.
Go LH, Corbridge TC
TheScientificWorldJournal 2011; 11:584-6
PMID: 21403976
Basic invasive mechanical ventilation.
Singer BD, Corbridge TC
Southern medical journal 2009 Dec; 102(12):1238-45
PMID: 20016432
Using simulation to enhance knowledge and confidence.
Corbridge SJ, McLaughlin R, Tiffen J, Wade L, Templin R, Corbridge TC
The Nurse practitioner 2008 Jun; 33(6):12-3
PMID: 18528196
David W. Cugell, MD
Lung Sounds and The Stethoscope — A Lung Sounds Primer.
Gavriely N, Cugell D, Zellner D
MedEdPORTAL 2012 Jan 03;
MEPID 9066
Gavriely N, Cugell D, Zellner D
MedEdPORTAL 2012 Jan 03;
MEPID 9066
Michael J. Cuttica, MD
Pulmonary hypertension in advanced chronic obstructive pulmonary disease.
Orr R, Smith LJ, Cuttica MJ
Current opinion in pulmonary medicine 2011 Dec 20; :
PMID: 22189454
Orr R, Smith LJ, Cuttica MJ
Current opinion in pulmonary medicine 2011 Dec 20; :
PMID: 22189454
Categorization and impact of pulmonary hypertension in patients with advanced COPD.
Cuttica MJ, Kalhan R, Shlobin OA, Ahmad S, Gladwin M, Machado RF, Barnett SD, Nathan SD
Respiratory medicine 2010 Jun 12; :
PMID: 20547449
Laura Dada, PhD
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.
Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI
Molecular and cellular biology 2011 Sep; 31(17):3546-56
PMID: 21730292
Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI
Molecular and cellular biology 2011 Sep; 31(17):3546-56
PMID: 21730292
Mitochondrial Ca²+ and ROS take center stage to orchestrate TNF-a-mediated inflammatory responses.
Dada LA, Sznajder JI
The Journal of clinical investigation 2011 May 2; 121(5):1683-5
PMID: 21519140
Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation.
Welch LC, Lecuona E, Briva A, Trejo HE, Dada LA, Sznajder JI
FEBS letters 2010 Sep 24; 584(18):3985-9
PMID: 20691686
E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation.
Yang Y, Do H, Tian X, Zhang C, Liu X, Dada LA, Sznajder JI, Liu J
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 27; 107(30):13444-9
PMID: 20624960
Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.
Comellas AP, Kelly AM, Trejo HE, Briva A, Lee J, Sznajder JI, Dada LA
Journal of cell science 2010 Apr 15; 123(Pt 8):1343-51
PMID: 20332111
Role of ubiquitination in Na,K-ATPase regulation during lung injury.
Helenius IT, Dada LA, Sznajder JI
Proceedings of the American Thoracic Society 2010 Feb; 7(1):65-70
PMID: 20160150
Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.
Zhou G, Dada LA, Wu M, Kelly A, Trejo H, Zhou Q, Varga J, Sznajder JI
American journal of physiology. Lung cellular and molecular physiology 2009 Dec; 297(6):L1120-30
PMID: 19801454
Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.
Gusarova GA, Dada LA, Kelly AM, Brodie C, Witters LA, Chandel NS, Sznajder JI
Molecular and cellular biology 2009 Jul; 29(13):3455-64
PMID: 19380482
Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor.
Comellas AP, Briva A, Dada LA, Butti ML, Trejo HE, Yshii C, Azzam ZS, Litvan J, Chen J, Lecuona E, Pesce LM, Yanagisawa M, Sznajder JI
American journal of respiratory and critical care medicine 2009 Jan 15; 179(2):113-22
PMID: 18948426
Regulation of alveolar epithelial function by hypoxia.
Zhou G, Dada LA, Sznajder JI
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008 May; 31(5):1107-13
PMID: 18448505
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.
Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI
The Journal of clinical investigation 2008 Feb; 118(2):752-62
PMID: 18188452
Jane E. Dematte D'Amico, MD
Risk assessment for inpatient survival in the long-term acute care setting after prolonged critical illness.
Dematte D'Amico JE, Donnelly HK, Mutlu GM, Feinglass J, Jovanovic BD, Ndukwu IM
Chest 2003 Sep; 124(3):1039-45
PMID: 12970035
Mechanisms of pulmonary edema clearance: from basic research to clinical implication.
Dematte JE, Sznajder JI
Intensive care medicine 2000 Apr; 26(4):477-80
PMID: 10872144
Khalilah L. Gates, MD
Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage.
Wang N, Gates KL, Trejo H, Favoreto S, Schleimer RP, Sznajder JI, Beitel GJ, Sporn PH
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jul; 24(7):2178-90
PMID: 20181940
Jeffrey L. Glassroth, MD
Nontuberculous mycobacterial lung diseases.
Taiwo B, Glassroth J
Infectious disease clinics of North America 2010 Sep; 24(3):769-89
PMID: 20674803
Pulmonary disease due to nontuberculous mycobacteria.
Glassroth J
Chest 2008 Jan; 133(1):243-51
PMID: 18187749
Cara Gottardi, PhD
{beta}-catenin/TCF signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.
Flozak AS, Lam AP, Russell S, Jain M, Peled ON, Sheppard KA, Beri R, Mutlu GM, Budinger GS, Gottardi CJ
The Journal of biological chemistry 2009 Nov 20; :
PMID: 19933277
The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex.
Mo R, Chew TL, Maher MT, Bellipanni G, Weinberg ES, Gottardi CJ
The Journal of biological chemistry 2009 Oct 9; 284(41):28222-31
PMID: 19706613
Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion.
Maher MT, Flozak AS, Stocker AM, Chenn A, Gottardi CJ
The Journal of cell biology 2009 Jul 27; 186(2):219-28
PMID: 19620634
Keenan A. Hawkins, MD
Lung Cancer in Chronic Obstructive Pulmonary Disease: Enhancing Surgical Options and Outcomes.
Raviv S, Hawkins KA, Decamp Jr MM, Kalhan R
American journal of respiratory and critical care medicine 2010 Dec 22; :
PMID: 21177883
Epithelial Cell Death is an Important Contributor to Oxidant-Mediated Acute Lung Injury.
Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS
American journal of respiratory and critical care medicine 2010 Oct 19; :
PMID: 20959557
Manu Jain, MD
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-{beta}1 signalling.
Mutlu GM, Budinger GR, Wu M, Lam AP, Zirk A, Rivera S, Urich D, Chiarella SE, Go LH, Ghosh AK, Selman M, Pardo A, Varga J, Kamp DW, Chandel NS, Sznajder JI, Jain M
Thorax 2011 Sep 15; :
PMID: 21921091
Nuclear {beta}-catenin is Increased in SSc Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation.
Lam AP, Flozak AS, Russell S, Wei J, Jain M, Mutlu GM, Budinger GR, Feghali-Bostwick CA, Varga J, Gottardi CJ
American journal of respiratory cell and molecular biology 2011 Apr 14; :
PMID: 21454805
Leptin Promotes Fibroproliferative ARDS by Inhibiting Peroxisome Proliferator-activated Receptor-{gamma}
Jain M, Budinger GS, Lo A, Urich D, Rivera SE, Ghosh AK, Gonzalez A, Chiarella SE, Marks K, Donnelly HK, Soberanes S, Varga J, Radigan KA, Chandel NS, Mutlu GM
American journal of respiratory and critical care medicine 2011 Feb 11; :
PMID: 21317313
Clinical significance of microbial infection and adaptation in cystic fibrosis.
Hauser AR, Jain M, Bar-Meir M, McColley SA
Clinical microbiology reviews 2011 Jan; 24(1):29-70
PMID: 21233507
Epithelial Cell Death is an Important Contributor to Oxidant-Mediated Acute Lung Injury.
Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS
American journal of respiratory and critical care medicine 2010 Oct 19; :
PMID: 20959557
Proteasomal regulation of pulmonary fibrosis.
Weiss CH, Budinger GR, Mutlu GM, Jain M
Proceedings of the American Thoracic Society 2010 Feb; 7(1):77-83
PMID: 20160152
PPAR¿ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis.
Wei J, Ghosh AK, Sargent JL, Komura K, Wu M, Huang QQ, Jain M, Whitfield ML, Feghali-Bostwick C, Varga J
PloS one 2010; 5(11):e13778
PMID: 21072170
{beta}-catenin/TCF signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.
Flozak AS, Lam AP, Russell S, Jain M, Peled ON, Sheppard KA, Beri R, Mutlu GM, Budinger GS, Gottardi CJ
The Journal of biological chemistry 2009 Nov 20; :
PMID: 19933277
Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways.
Chandel NS, Budinger GR, Mutlu GM, Varga J, Synenki L, Donnelly HK, Zirk A, Eisenbart J, Jovanovic B, Jain M
Critical care medicine 2009 May; 37(5):1678-84
PMID: 19325470
Head CT is of limited diagnostic value in critically ill patients who remain unresponsive after discontinuation of sedation.
Balachandran JS, Jaleel M, Jain M, Mahajan N, Kalhan R, Balagani R, Donnelly HK, Greenstein E, Mutlu GM
BMC anesthesiology 2009; 9:3
PMID: 19422697
BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK.
Shroff EH, Snyder CM, Budinger GR, Jain M, Chew TL, Khuon S, Perlman H, Chandel NS
PloS one 2009; 4(5):e5646
PMID: 19468307
Evolution of Pseudomonas aeruginosa type III secretion in cystic fibrosis: a paradigm of chronic infection.
Jain M, Bar-Meir M, McColley S, Cullina J, Potter E, Powers C, Prickett M, Seshadri R, Jovanovic B, Petrocheilou A, King JD, Hauser AR
Translational research : the journal of laboratory and clinical medicine 2008 Dec; 152(6):257-64
PMID: 19059160
Peripheral airways injury in acute lung injury/acute respiratory distress syndrome.
Jain M, Sznajder JI
Current opinion in critical care 2008 Feb; 14(1):37-43
PMID: 18195624
Ravi Kalhan, MD, MS
Lung Cancer in Chronic Obstructive Pulmonary Disease: Enhancing Surgical Options and Outcomes.
Raviv S, Hawkins KA, Decamp Jr MM, Kalhan R
American journal of respiratory and critical care medicine 2010 Dec 22; :
PMID: 21177883
Lung function in young adults predicts airflow obstruction 20 years later.
Kalhan R, Arynchyn A, Colangelo LA, Dransfield MT, Gerald LB, Smith LJ
The American journal of medicine 2010 May; 123(5):468.e1-7
PMID: 20399325
Systemic inflammation in young adults is associated with abnormal lung function in middle age.
Kalhan R, Tran BT, Colangelo LA, Rosenberg SR, Liu K, Thyagarajan B, Jacobs DR, Smith LJ
PloS one 2010; 5(7):e11431
PMID: 20625390
Hyperinflation is associated with lower sleep efficiency in COPD with co-existent obstructive sleep apnea.
Kwon JS, Wolfe LF, Lu BS, Kalhan R
COPD 2009 Dec; 6(6):441-5
PMID: 19938967
Rate of Decline of Forced Vital Capacity Predicts Future Arterial Hypertension: The Coronary Artery Risk Development in Young Adults Study.
Jacobs DR, Yatsuya H, Hearst MO, Thyagarajan B, Kalhan R, Rosenberg S, Smith LJ, Barr RG, Duprez DA
Hypertension 2011 Dec 27; :
PMID: 22203738
Lung spirometry parameters and diffusion capacity are decreased in patients with Type 2 diabetes.
Klein OL, Kalhan R, Williams MV, Tipping M, Lee J, Peng J, Smith LJ
Diabetic medicine : a journal of the British Diabetic Association 2011 Jul 25; :
PMID: 21790775
Dying from, and with, chronic obstructive pulmonary disease.
Rosenberg SR, Kalhan R
American journal of respiratory and critical care medicine 2011 Apr 15; 183(8):960-2
PMID: 21498816
Barriers to adherence to chronic obstructive pulmonary disease guidelines by primary care physicians.
Salinas GD, Williamson JC, Kalhan R, Thomashow B, Scheckermann JL, Walsh J, Abdolrasulnia M, Foster JA
International journal of chronic obstructive pulmonary disease 2011; 6:171-9
PMID: 21468169
Serum adiponectin is positively associated with lung function in young adults, independent of obesity: The CARDIA study.
Thyagarajan B, Jacobs DR, Smith LJ, Kalhan R, Gross MD, Sood A
Respiratory research 2010 Dec 9; 11(1):176
PMID: 21143922
Effect of Obesity on Asthma Phenotype is Dependent upon Asthma Severity.
Raviv S, Dixon AE, Kalhan R, Shade D, Smith LJ
The Journal of asthma : official journal of the Association for the Care of Asthma 2010 Nov 22; :
PMID: 21091180
Categorization and impact of pulmonary hypertension in patients with advanced COPD.
Cuttica MJ, Kalhan R, Shlobin OA, Ahmad S, Gladwin M, Machado RF, Barnett SD, Nathan SD
Respiratory medicine 2010 Jun 12; :
PMID: 20547449
Spirometry guidelines influence lung function results in a longitudinal study of young adults.
Smith LJ, Arynchyn A, Kalhan R, Williams OD, Jensen R, Crapo R, Jacobs DR
Respiratory medicine 2010 Jun; 104(6):858-64
PMID: 20047823
Association of Circulating Adhesion Molecules With Lung Function: The CARDIA Study.
Thyagarajan B, Smith LJ, Barr RG, Gross MD, Sood A, Kalhan R, Jacobs DR
Chest 2009 Feb 18; :
PMID: 19225066
Head CT is of limited diagnostic value in critically ill patients who remain unresponsive after discontinuation of sedation.
Balachandran JS, Jaleel M, Jain M, Mahajan N, Kalhan R, Balagani R, Donnelly HK, Greenstein E, Mutlu GM
BMC anesthesiology 2009; 9:3
PMID: 19422697
Potential reasons why physicians underuse lung-protective ventilation: a retrospective cohort study using physician documentation.
Mikkelsen ME, Dedhiya PM, Kalhan R, Gallop RJ, Lanken PN, Fuchs BD
Respiratory care 2008 Apr; 53(4):455-61
PMID: 18364057
A 23-year-old woman with sudden-onset dyspnea and chest pain penetrating to the back.
Kwon JS, Blum MG, Kalhan R
Chest 2008 Feb; 133(2):574-8
PMID: 18252926
A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis.
Kalhan R, Smith LJ, Nlend MC, Nair A, Hixon JL, Sporn PH
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008 Jan; 38(1):103-12
PMID: 17979994
David W. Kamp, MD
Molecular mechanisms of asbestos-induced lung epithelial cell apoptosis.
Liu G, Beri R, Mueller A, Kamp DW
Chemico-biological interactions 2010 Nov 5; 188(2):309-18
PMID: 20380827
Role of mitochondrial hOgg1 and aconitase in oxidant-induced lung epithelial cell apoptosis.
Panduri V, Liu G, Surapureddi S, Kondapalli J, Soberanes S, de Souza-Pinto NC, Bohr VA, Budinger GR, Schumacker PT, Weitzman SA, Kamp DW
Free radical biology & medicine 2009 Jun 11; :
PMID: 19524665
Asbestos-induced lung diseases: an update.
Kamp DW
Translational research : the journal of laboratory and clinical medicine 2009 Apr; 153(4):143-52
PMID: 19304273
Ai P Lam, MD
Nuclear {beta}-catenin is Increased in SSc Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation.
Lam AP, Flozak AS, Russell S, Wei J, Jain M, Mutlu GM, Budinger GR, Feghali-Bostwick CA, Varga J, Gottardi CJ
American journal of respiratory cell and molecular biology 2011 Apr 14; :
PMID: 21454805
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?
Wei J, Melichian D, Komura K, Hinchcliff M, Lam AP, Lafyatis R, Gottardi CJ, Macdougald OA, Varga J
Arthritis and rheumatism 2011 Mar 2; :
PMID: 21370225
Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis.
Young LR, Franz DN, Nagarkatte P, Fletcher CD, Wikenheiser-Brokamp KA, Galsky MD, Corbridge TC, Lam AP, Gelfand MJ, McCormack FX
Chest 2009 Sep; 136(3):926-33
PMID: 19349386
Emilia Lecuona, PhD
Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions.
Lecuona E, Sun H, Vohwinkel C, Ciechanover A, Sznajder JI
American journal of respiratory cell and molecular biology 2009 Dec; 41(6):671-9
PMID: 19286978
Myosin-Va restrains the trafficking of Na+/K+-ATPase-containing vesicles in alveolar epithelial cells.
Lecuona E, Minin A, Trejo HE, Chen J, Comellas AP, Sun H, Grillo D, Nekrasova OE, Welch LC, Szleifer I, Gelfand VI, Sznajder JI
Journal of cell science 2009 Nov 1; 122(Pt 21):3915-22
PMID: 19808891
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.
Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI
The Journal of clinical investigation 2008 Feb; 118(2):752-62
PMID: 18188452
Jing Liu, PhD
E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation.
Yang Y, Do H, Tian X, Zhang C, Liu X, Dada LA, Sznajder JI, Liu J
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 27; 107(30):13444-9
PMID: 20624960
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR
The Journal of biological chemistry 2009 Jan 23; 284(4):2176-86
PMID: 19033436
Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members.
Snyder CM, Shroff EH, Liu J, Chandel NS
PloS one 2009; 4(9):e7059
PMID: 19768117
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
Emerling BM, Weinberg F, Liu JL, Mak TW, Chandel NS
Proceedings of the National Academy of Sciences of the United States of America 2008 Feb 19; 105(7):2622-7
PMID: 18268343
Gokhan M. Mutlu, MD
Leptin Promotes Fibroproliferative ARDS by Inhibiting Peroxisome Proliferator-activated Receptor-{gamma}
Jain M, Budinger GS, Lo A, Urich D, Rivera SE, Ghosh AK, Gonzalez A, Chiarella SE, Marks K, Donnelly HK, Soberanes S, Varga J, Radigan KA, Chandel NS, Mutlu GM
American journal of respiratory and critical care medicine 2011 Feb 11; :
PMID: 21317313
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.
Mutlu GM, Green D, Bellmeyer A, Baker CM, Burgess Z, Rajamannan N, Christman JW, Foiles N, Kamp DW, Ghio AJ, Chandel NS, Dean DA, Sznajder JI, Budinger GR
The Journal of clinical investigation 2007 Oct; 117(10):2952-61
PMID: 17885684
Leptin resistance protects mice from hyperoxia-induced acute lung injury.
Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM
American journal of respiratory and critical care medicine 2007 Mar 15; 175(6):587-94
PMID: 17185651
Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling.
Mutlu GM, Dumasius V, Burhop J, McShane PJ, Meng FJ, Welch L, Dumasius A, Mohebahmadi N, Thakuria G, Hardiman K, Matalon S, Hollenberg S, Factor P
Circulation research 2004 Apr 30; 94(8):1091-100
PMID: 15016730
Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.
Duch MC, Budinger GR, Liang YT, Soberanes S, Urich D, Chiarella SE, Campochiaro LA, Gonzalez A, Chandel NS, Hersam MC, Mutlu GM
Nano letters 2011 Dec 14; 11(12):5201-7
PMID: 22023654
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-{beta}1 signalling.
Mutlu GM, Budinger GR, Wu M, Lam AP, Zirk A, Rivera S, Urich D, Chiarella SE, Go LH, Ghosh AK, Selman M, Pardo A, Varga J, Kamp DW, Chandel NS, Sznajder JI, Jain M
Thorax 2011 Sep 15; :
PMID: 21921091
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.
Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI
Molecular and cellular biology 2011 Sep; 31(17):3546-56
PMID: 21730292
Linking air pollution exposure with thrombosis.
Mutlu GM, Bryce PJ, Budinger GR
Blood 2011 Sep 1; 118(9):2636-7
PMID: 21885614
Update in environmental and occupational medicine 2010.
Budinger GR, Mutlu GM
American journal of respiratory and critical care medicine 2011 Jun 15; 183(12):1614-9
PMID: 21693716
Nuclear {beta}-catenin is Increased in SSc Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation.
Lam AP, Flozak AS, Russell S, Wei J, Jain M, Mutlu GM, Budinger GR, Feghali-Bostwick CA, Varga J, Gottardi CJ
American journal of respiratory cell and molecular biology 2011 Apr 14; :
PMID: 21454805
Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice.
Mutlu EA, Engen PA, Soberanes S, Urich D, Forsyth CB, Nigdelioglu R, Chiarella SE, Radigan KA, Gonzalez A, Jakate S, Keshavarzian A, Budinger GR, Mutlu GM
Particle and fibre toxicology 2011; 8:19
PMID: 21658250
Particulate Matter-Induced Lung Inflammation Increases Systemic Levels of PAI-1 and Activates Coagulation Through Distinct Mechanisms.
Budinger GR, McKell JL, Urich D, Foiles N, Weiss I, Chiarella SE, Gonzalez A, Soberanes S, Ghio AJ, Nigdelioglu R, Mutlu EA, Radigan KA, Green D, Kwaan HC, Mutlu GM
PloS one 2011; 6(4):e18525
PMID: 21494547
Epithelial Cell Death is an Important Contributor to Oxidant-Mediated Acute Lung Injury.
Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS
American journal of respiratory and critical care medicine 2010 Oct 19; :
PMID: 20959557
Coma with absent brainstem reflexes resulting from zolpidem overdose.
Kuzniar TJ, Balagani R, Radigan KA, Factor P, Mutlu GM
American journal of therapeutics 2010 Sep-Oct; 17(5):e172-4
PMID: 20862780
Joubert syndrome associated with severe central sleep apnea.
Wolfe L, Lakadamyali H, Mutlu GM
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2010 Aug 15; 6(4):384-8
PMID: 20726289
Update in environmental and occupational medicine 2009.
Van Hee VC, Kaufman JD, Budinger GR, Mutlu GM
American journal of respiratory and critical care medicine 2010 Jun 1; 181(11):1174-80
PMID: 20516491
Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity.
Mutlu GM, Budinger GR, Green AA, Urich D, Soberanes S, Chiarella SE, Alheid GF, McCrimmon DR, Szleifer I, Hersam MC
Nano letters 2010 May 12; 10(5):1664-70
PMID: 20377197
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS
Proceedings of the National Academy of Sciences of the United States of America 2010 May 11; 107(19):8788-93
PMID: 20421486
Proteasomal regulation of pulmonary fibrosis.
Weiss CH, Budinger GR, Mutlu GM, Jain M
Proceedings of the American Thoracic Society 2010 Feb; 7(1):77-83
PMID: 20160152
Not much turbulence: addition of heliox to noninvasive ventilation fails to improve outcomes in patients with exacerbations of chronic obstructive pulmonary disease.
Mutlu GM, Budinger GR
Critical care medicine 2010 Jan; 38(1):319-20
PMID: 20023482
Dysphonia and chest pain as presenting symptoms of pneumomediastinum.
Mork T, Mutlu GM, Kuzniar TJ
Tüberküloz ve toraks 2010; 58(2):184-7
PMID: 20865573
Adenosine A1 receptor, a target and regulator of estrogen receptoralpha action, mediates the proliferative effects of estradiol in breast cancer.
Lin Z, Yin P, Reierstad S, O'Halloran M, Coon V JS, Pearson EK, Mutlu GM, Bulun SE
Oncogene 2009 Nov 23; :
PMID: 19935720
{beta}-catenin/TCF signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.
Flozak AS, Lam AP, Russell S, Jain M, Peled ON, Sheppard KA, Beri R, Mutlu GM, Budinger GS, Gottardi CJ
The Journal of biological chemistry 2009 Nov 20; :
PMID: 19933277
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.
Urich D, Soberanes S, Burgess Z, Chiarella SE, Ghio AJ, Ridge KM, Kamp DW, Chandel NS, Mutlu GM, Budinger GR
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Jul; 23(7):2055-64
PMID: 19237507
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.
Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, Budinger GR, Chandel NS
Free radical biology & medicine 2009 May 15; 46(10):1386-91
PMID: 19268526
Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways.
Chandel NS, Budinger GR, Mutlu GM, Varga J, Synenki L, Donnelly HK, Zirk A, Eisenbart J, Jovanovic B, Jain M
Critical care medicine 2009 May; 37(5):1678-84
PMID: 19325470
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR
The Journal of biological chemistry 2009 Jan 23; 284(4):2176-86
PMID: 19033436
Head CT is of limited diagnostic value in critically ill patients who remain unresponsive after discontinuation of sedation.
Balachandran JS, Jaleel M, Jain M, Mahajan N, Kalhan R, Balagani R, Donnelly HK, Greenstein E, Mutlu GM
BMC anesthesiology 2009; 9:3
PMID: 19422697
Stretch-induced activation of AMP kinase in the lung requires dystroglycan.
Budinger GR, Urich D, DeBiase PJ, Chiarella SE, Burgess ZO, Baker CM, Soberanes S, Mutlu GM, Jones JC
American journal of respiratory cell and molecular biology 2008 Dec; 39(6):666-72
PMID: 18556591
Alveolar epithelial beta2-adrenergic receptors.
Mutlu GM, Factor P
American journal of respiratory cell and molecular biology 2008 Feb; 38(2):127-34
PMID: 17709598
Karen M. Ridge, PhD
Mitochondrial reactive oxygen species are required for hypoxia-induced degradation of keratin intermediate filaments.
Na N, Chandel NS, Litvan J, Ridge KM
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Nov 6; :
PMID: 19897662
Shear Stress Induced Reorganization of the Keratin Intermediate Filament Network Requires Phosphorylation by PKC {zeta}
Sivaramakrishnan S, Schneider JL, Sitikov A, Goldman RD, Ridge KM
Molecular biology of the cell 2009 Apr 8; :
PMID: 19357195
Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells.
Jaitovich A, Mehta S, Na N, Ciechanover A, Goldman RD, Ridge KM
The Journal of biological chemistry 2008 Sep 12; 283(37):25348-55
PMID: 18617517
Micromechanical properties of keratin intermediate filament networks.
Sivaramakrishnan S, DeGiulio JV, Lorand L, Goldman RD, Ridge KM
Proceedings of the National Academy of Sciences of the United States of America 2008 Jan 22; 105(3):889-94
PMID: 18199836
Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells.
Rogel MR, Soni PN, Troken JR, Sitikov A, Trejo HE, Ridge KM
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Nov; 25(11):3873-83
PMID: 21803859
The role of the ubiquitin proteasome pathway in keratin intermediate filament protein degradation.
Rogel MR, Jaitovich A, Ridge KM
Proceedings of the American Thoracic Society 2010 Feb; 7(1):71-6
PMID: 20160151
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.
Urich D, Soberanes S, Burgess Z, Chiarella SE, Ghio AJ, Ridge KM, Kamp DW, Chandel NS, Mutlu GM, Budinger GR
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Jul; 23(7):2055-64
PMID: 19237507
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR
The Journal of biological chemistry 2009 Jan 23; 284(4):2176-86
PMID: 19033436
Overexpression of the Na-K-ATPase alpha2-subunit improves lung liquid clearance during ventilation-induced lung injury.
Adir Y, Welch LC, Dumasius V, Factor P, Sznajder JI, Ridge KM
American journal of physiology. Lung cellular and molecular physiology 2008 Jun; 294(6):L1233-7
PMID: 18424620
Lewis J. Smith, MD
Lung function in young adults predicts airflow obstruction 20 years later.
Kalhan R, Arynchyn A, Colangelo LA, Dransfield MT, Gerald LB, Smith LJ
The American journal of medicine 2010 May; 123(5):468.e1-7
PMID: 20399325
Systemic inflammation in young adults is associated with abnormal lung function in middle age.
Kalhan R, Tran BT, Colangelo LA, Rosenberg SR, Liu K, Thyagarajan B, Jacobs DR, Smith LJ
PloS one 2010; 5(7):e11431
PMID: 20625390
A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis.
Kalhan R, Smith LJ, Nlend MC, Nair A, Hixon JL, Sporn PH
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008 Jan; 38(1):103-12
PMID: 17979994
Randomized comparison of strategies for reducing treatment in mild persistent asthma.
No authors listed, Peters SP, Anthonisen N, Castro M, Holbrook JT, Irvin CG, Smith LJ, Wise RA
The New England journal of medicine 2007 May 17; 356(20):2027-39
PMID: 17507702
Rate of Decline of Forced Vital Capacity Predicts Future Arterial Hypertension: The Coronary Artery Risk Development in Young Adults Study.
Jacobs DR, Yatsuya H, Hearst MO, Thyagarajan B, Kalhan R, Rosenberg S, Smith LJ, Barr RG, Duprez DA
Hypertension 2011 Dec 27; :
PMID: 22203738
Pulmonary hypertension in advanced chronic obstructive pulmonary disease.
Orr R, Smith LJ, Cuttica MJ
Current opinion in pulmonary medicine 2011 Dec 20; :
PMID: 22189454
Lung spirometry parameters and diffusion capacity are decreased in patients with Type 2 diabetes.
Klein OL, Kalhan R, Williams MV, Tipping M, Lee J, Peng J, Smith LJ
Diabetic medicine : a journal of the British Diabetic Association 2011 Jul 25; :
PMID: 21790775
Reduced diffusion lung capacity in patients with type 2 diabetes mellitus predicts hospitalization for pneumonia.
Klein OL, Smith LJ, Tipping M, Peng J, Williams MV
Diabetes research and clinical practice 2011 Apr; 92(1):e12-5
PMID: 21237523
Socioeconomic status is positively associated with percent emphysema on CT scan: The MESA lung study.
Lovasi GS, Diez Roux AV, Hoffman EA, Smith LJ, Jiang R, Carr JJ, Barr RG
Academic radiology 2011 Feb; 18(2):199-204
PMID: 21232685
Serum adiponectin is positively associated with lung function in young adults, independent of obesity: The CARDIA study.
Thyagarajan B, Jacobs DR, Smith LJ, Kalhan R, Gross MD, Sood A
Respiratory research 2010 Dec 9; 11(1):176
PMID: 21143922
Effect of Obesity on Asthma Phenotype is Dependent upon Asthma Severity.
Raviv S, Dixon AE, Kalhan R, Shade D, Smith LJ
The Journal of asthma : official journal of the Association for the Care of Asthma 2010 Nov 22; :
PMID: 21091180
Anticholinergics for patients with asthma?
Smith LJ
The New England journal of medicine 2010 Oct 28; 363(18):1764-5
PMID: 20979479
Systematic review of the association between lung function and Type 2 diabetes mellitus.
Klein OL, Krishnan JA, Glick S, Smith LJ
Diabetic medicine : a journal of the British Diabetic Association 2010 Sep; 27(9):977-87
PMID: 20722670
Genetic ancestry in lung-function predictions.
Kumar R, Seibold MA, Aldrich MC, Williams LK, Reiner AP, Colangelo L, Galanter J, Gignoux C, Hu D, Sen S, Choudhry S, Peterson EL, Rodriguez-Santana J, Rodriguez-Cintron W, Nalls MA, Leak TS, O'Meara E, Meibohm B, Kritchevsky SB, Li R, Harris TB, Nickerson DA, Fornage M, Enright P, Ziv E, Smith LJ, Liu K, Burchard EG
The New England journal of medicine 2010 Jul 22; 363(4):321-30
PMID: 20647190
Spirometry guidelines influence lung function results in a longitudinal study of young adults.
Smith LJ, Arynchyn A, Kalhan R, Williams OD, Jensen R, Crapo R, Jacobs DR
Respiratory medicine 2010 Jun; 104(6):858-64
PMID: 20047823
Prospective measurements of intra-abdominal volume and pulmonary function after repair of massive ventral hernias with the components separation technique.
Agnew SP, Small W, Wang E, Smith LJ, Hadad I, Dumanian GA
Annals of surgery 2010 May; 251(5):981-8
PMID: 20395855
The association of pipe and cigar use with cotinine levels, lung function, and airflow obstruction: a cross-sectional study.
Rodriguez J, Jiang R, Johnson WC, MacKenzie BA, Smith LJ, Barr RG
Annals of internal medicine 2010 Feb 16; 152(4):201-10
PMID: 20157134
Percent emphysema, airflow obstruction, and impaired left ventricular filling.
Barr RG, Bluemke DA, Ahmed FS, Carr JJ, Enright PL, Hoffman EA, Jiang R, Kawut SM, Kronmal RA, Lima JA, Shahar E, Smith LJ, Watson KE
The New England journal of medicine 2010 Jan 21; 362(3):217-27
PMID: 20089972
Diet and asthma.
Raviv S, Smith LJ
Current opinion in pulmonary medicine 2010 Jan; 16(1):71-6
PMID: 19738468
Performance of American Thoracic Society-recommended spirometry reference values in a multiethnic sample of adults: the multi-ethnic study of atherosclerosis (MESA) lung study.
Hankinson JL, Kawut SM, Shahar E, Smith LJ, Stukovsky KH, Barr RG
Chest 2010 Jan; 137(1):138-45
PMID: 19741060
Obesity-asthma association: is it explained by systemic oxidant stress?
Sood A, Qualls C, Arynchyn A, Beckett WS, Gross MD, Steffes MW, Smith LJ, Holvoet P, Thyagarajan B, Jacobs DR
Chest 2009 Oct; 136(4):1055-62
PMID: 19592473
Association of Circulating Adhesion Molecules With Lung Function: The CARDIA Study.
Thyagarajan B, Smith LJ, Barr RG, Gross MD, Sood A, Kalhan R, Jacobs DR
Chest 2009 Feb 18; :
PMID: 19225066
Association between asthma and serum adiponectin concentration in women.
Sood A, Cui X, Qualls C, Beckett WS, Gross MD, Steffes MW, Smith LJ, Jacobs DR
Thorax 2008 Oct; 63(10):877-82
PMID: 18390629
Longitudinal association of body mass index with lung function: the CARDIA study.
Thyagarajan B, Jacobs DR, Apostol GG, Smith LJ, Jensen RL, Crapo RO, Barr RG, Lewis CE, Williams OD
Respiratory research 2008; 9:31
PMID: 18394165
Peter H. S. Sporn, MD
Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage.
Wang N, Gates KL, Trejo H, Favoreto S, Schleimer RP, Sznajder JI, Beitel GJ, Sporn PH
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jul; 24(7):2178-90
PMID: 20181940
Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection.
Helenius IT, Krupinski T, Turnbull DW, Gruenbaum Y, Silverman N, Johnson EA, Sporn PH, Sznajder JI, Beitel GJ
Proceedings of the National Academy of Sciences of the United States of America 2009 Nov 3; 106(44):18710-5
PMID: 19846771
A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis.
Kalhan R, Smith LJ, Nlend MC, Nair A, Hixon JL, Sporn PH
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008 Jan; 38(1):103-12
PMID: 17979994
Jacob Iasha Sznajder, MD
Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation.
Vohwinkel CU, Lecuona E, Sun H, Sommer N, Vadász I, Chandel NS, Sznajder JI
The Journal of biological chemistry 2011 Oct 28; 286(43):37067-76
PMID: 21903582
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-{beta}1 signalling.
Mutlu GM, Budinger GR, Wu M, Lam AP, Zirk A, Rivera S, Urich D, Chiarella SE, Go LH, Ghosh AK, Selman M, Pardo A, Varga J, Kamp DW, Chandel NS, Sznajder JI, Jain M
Thorax 2011 Sep 15; :
PMID: 21921091
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.
Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI
Molecular and cellular biology 2011 Sep; 31(17):3546-56
PMID: 21730292
Mitochondrial Ca²+ and ROS take center stage to orchestrate TNF-a-mediated inflammatory responses.
Dada LA, Sznajder JI
The Journal of clinical investigation 2011 May 2; 121(5):1683-5
PMID: 21519140
Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation.
Welch LC, Lecuona E, Briva A, Trejo HE, Dada LA, Sznajder JI
FEBS letters 2010 Sep 24; 584(18):3985-9
PMID: 20691686
E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation.
Yang Y, Do H, Tian X, Zhang C, Liu X, Dada LA, Sznajder JI, Liu J
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 27; 107(30):13444-9
PMID: 20624960
Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage.
Wang N, Gates KL, Trejo H, Favoreto S, Schleimer RP, Sznajder JI, Beitel GJ, Sporn PH
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jul; 24(7):2178-90
PMID: 20181940
Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.
Comellas AP, Kelly AM, Trejo HE, Briva A, Lee J, Sznajder JI, Dada LA
Journal of cell science 2010 Apr 15; 123(Pt 8):1343-51
PMID: 20332111
Role of ubiquitination in Na,K-ATPase regulation during lung injury.
Helenius IT, Dada LA, Sznajder JI
Proceedings of the American Thoracic Society 2010 Feb; 7(1):65-70
PMID: 20160150
Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.
Zhou G, Dada LA, Wu M, Kelly A, Trejo H, Zhou Q, Varga J, Sznajder JI
American journal of physiology. Lung cellular and molecular physiology 2009 Dec; 297(6):L1120-30
PMID: 19801454
Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions.
Lecuona E, Sun H, Vohwinkel C, Ciechanover A, Sznajder JI
American journal of respiratory cell and molecular biology 2009 Dec; 41(6):671-9
PMID: 19286978
Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection.
Helenius IT, Krupinski T, Turnbull DW, Gruenbaum Y, Silverman N, Johnson EA, Sporn PH, Sznajder JI, Beitel GJ
Proceedings of the National Academy of Sciences of the United States of America 2009 Nov 3; 106(44):18710-5
PMID: 19846771
Myosin-Va restrains the trafficking of Na+/K+-ATPase-containing vesicles in alveolar epithelial cells.
Lecuona E, Minin A, Trejo HE, Chen J, Comellas AP, Sun H, Grillo D, Nekrasova OE, Welch LC, Szleifer I, Gelfand VI, Sznajder JI
Journal of cell science 2009 Nov 1; 122(Pt 21):3915-22
PMID: 19808891
Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells.
Trejo HE, Lecuona E, Grillo D, Szleifer I, Nekrasova OE, Gelfand VI, Sznajder JI
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Sep 22; :
PMID: 19773350
Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.
Gusarova GA, Dada LA, Kelly AM, Brodie C, Witters LA, Chandel NS, Sznajder JI
Molecular and cellular biology 2009 Jul; 29(13):3455-64
PMID: 19380482
Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor.
Comellas AP, Briva A, Dada LA, Butti ML, Trejo HE, Yshii C, Azzam ZS, Litvan J, Chen J, Lecuona E, Pesce LM, Yanagisawa M, Sznajder JI
American journal of respiratory and critical care medicine 2009 Jan 15; 179(2):113-22
PMID: 18948426
Overexpression of the Na-K-ATPase alpha2-subunit improves lung liquid clearance during ventilation-induced lung injury.
Adir Y, Welch LC, Dumasius V, Factor P, Sznajder JI, Ridge KM
American journal of physiology. Lung cellular and molecular physiology 2008 Jun; 294(6):L1233-7
PMID: 18424620
Regulation of alveolar epithelial function by hypoxia.
Zhou G, Dada LA, Sznajder JI
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008 May; 31(5):1107-13
PMID: 18448505
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.
Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI
The Journal of clinical investigation 2008 Feb; 118(2):752-62
PMID: 18188452
Peripheral airways injury in acute lung injury/acute respiratory distress syndrome.
Jain M, Sznajder JI
Current opinion in critical care 2008 Feb; 14(1):37-43
PMID: 18195624
Improving survival by increasing lung edema clearance: is airspace delivery of dopamine a solution?
Jaitovich A, Sznajder JI
Critical care (London, England) 2008; 12(2):135
PMID: 18439324
Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia.
Chen J, Lecuona E, Briva A, Welch LC, Sznajder JI
American journal of respiratory cell and molecular biology 2008 Jan; 38(1):32-7
PMID: 17690328
Lisa F. Wolfe, MD
Hyperinflation is associated with lower sleep efficiency in COPD with co-existent obstructive sleep apnea.
Kwon JS, Wolfe LF, Lu BS, Kalhan R
COPD 2009 Dec; 6(6):441-5
PMID: 19938967
Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis.
Molteni A, Wolfe LF, Ward WF, Ts'ao CH, Molteni LB, Veno P, Fish BL, Taylor JM, Quintanilla N, Herndon B, Moulder JE
Current pharmaceutical design 2007; 13(13):1307-16
PMID: 17506716
Responsiveness of the aging circadian clock to light.
Benloucif S, Green K, L'Hermite-Balériaux M, Weintraub S, Wolfe LF, Zee PC
Neurobiology of aging 2006 Dec; 27(12):1870-9
PMID: 16309797
Cystic fibrosis patients have poor sleep quality despite normal sleep latency and efficiency.
Jankelowitz L, Reid KJ, Wolfe L, Cullina J, Zee PC, Jain M
Chest 2005 May; 127(5):1593-9
PMID: 15888833
Richard G. Wunderink, MD
Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults.
Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM, Musher DM, Niederman MS, Torres A, Whitney CG
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007 Mar 1; 44 Suppl 2:S27-72
PMID: 17278083
Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia.
No authors listed
American journal of respiratory and critical care medicine 2005 Feb 15; 171(4):388-416
PMID: 15699079
Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia.
Wunderink RG, Rello J, Cammarata SK, Croos-Dabrera RV, Kollef MH
Chest 2003 Nov; 124(5):1789-97
PMID: 14605050
Septic shock and respiratory failure in community-acquired pneumonia have different TNF polymorphism associations.
Waterer GW, Quasney MW, Cantor RM, Wunderink RG
American journal of respiratory and critical care medicine 2001 Jun; 163(7):1599-604
PMID: 11401880
Update in pulmonary infections 2010.
Wunderink RG, Waterer GW
American journal of respiratory and critical care medicine 2011 Jul 15; 184(2):186-90
PMID: 21765033
Recombinant Tissue Factor Pathway Inhibitor in Severe Community-Acquired Pneumonia: A Randomized Trial.
Wunderink RG, Laterre PF, Francois B, Perrotin D, Artigas A, Vidal LO, Lobo SM, San Juan J, Hwang SC, Dugernier T, Larosa S, Wittebole X, Dhainaut JF, Doig C, Mendelson MH, Zwingelstein C, Su G, Opal S
American journal of respiratory and critical care medicine 2011 Feb 4; :
PMID: 21297074
Surrogate markers and microbiologic end points.
Wunderink RG
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010 Aug 1; 51 Suppl 1:S126-30
PMID: 20597662
Expanded clinical presentation of community-acquired methicillin-resistant Staphylococcus aureus pneumonia.
Lobo LJ, Reed KD, Wunderink RG
Chest 2010 Jul; 138(1):130-6
PMID: 20173050
Comparative in vitro stimulation with lipopolysaccharide to study TNFalpha gene expression in fresh whole blood, fresh and frozen peripheral blood mononuclear cells.
Chen J, Bruns AH, Donnelly HK, Wunderink RG
Journal of immunological methods 2010 May 31; 357(1-2):33-7
PMID: 20307542
Influenza and bacterial pneumonia--constant companions.
Wunderink RG
Critical care (London, England) 2010; 14(3):150
PMID: 20500906
Adjunctive therapy in community-acquired pneumonia.
Wunderink RG
Seminars in respiratory and critical care medicine 2009 Apr; 30(2):146-53
PMID: 19296414
The role of MRSA in healthcare-associated pneumonia.
Lam AP, Wunderink RG
Seminars in respiratory and critical care medicine 2009 Feb; 30(1):52-60
PMID: 19199187
Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus.
Wunderink RG, Mendelson MH, Somero MS, Fabian TC, May AK, Bhattacharyya H, Leeper KV, Solomkin JS
Chest 2008 Dec; 134(6):1200-7
PMID: 18719064
Scenario 2: community-acquired pneumonia requiring hospitalization but not requiring admission to an intensive care unit.
Wunderink RG
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008 Dec 1; 47 Suppl 3:S186-8
PMID: 18986287
Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: a multicenter, randomized study.
Chastre J, Wunderink R, Prokocimer P, Lee M, Kaniga K, Friedland I
Critical care medicine 2008 Apr; 36(4):1089-96
PMID: 18379232
Gene expression profiling in acute respiratory distress syndrome: pathways to future interventions.
Wunderink RG
Critical care medicine 2008 Mar; 36(3):1014-5
PMID: 18431309
Ventilator-associated pneumonia: Lessons learned from clinical trials.
Wunderink RG, Brun-Buisson C
Journal of critical care 2008 Mar; 23(1):2-4
PMID: 18359414
Evaluation of ICU admission criteria and diagnostic methods for patients with severe community-acquired pneumonia: current practice survey.
Restrepo MI, Bienen T, Mortensen EM, Anzueto A, Metersky ML, Escalante P, Wunderink RG, Mangura BT
Chest 2008 Mar; 133(3):828-9
PMID: 18321916
There is no "cap" on the importance of community-acquired pneumonia in the ICU.
Shorr AF, Wunderink RG
Chest 2008 Mar; 133(3):590-2
PMID: 18321897
A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome*
Morris PE, Papadakos P, Russell JA, Wunderink R, Schuster DP, Truwit JD, Vincent JL, Bernard GR
Crit Care Med 2008 Jan 18; :
PMID: 18209670
Derivation of a triage algorithm for chest radiography of community-acquired pneumonia patients in the emergency department.
Kyriacou DN, Yarnold PR, Soltysik RC, Self WH, Wunderink RG, Schmitt BP, Parada JP, Adams JG
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2008 Jan; 15(1):40-4
PMID: 18211312
