Northwestern University Feinberg School of Medicine

Department of Medicine

Chonghui  Cheng, MD, PhD

Chonghui Cheng, MD, PhD

Adjunct Associate Professor of Medicine (Hematology and Oncology)

Focus of Work

Bio

Current research in the Cheng lab focuses on investigating breast cancer metastasis regulated at the level of RNA. One of the biggest surprises from genome sequencing projects is that nearly all human genes undergo alternative splicing. Inevitably, dysregulation of alternative splicing has been associated with hallmarks of cancer for over a decade. An outstanding question that remains is: Of the many alternative splicing events that occur in cancer, which events are the important drivers of carc...[Read full text]Current research in the Cheng lab focuses on investigating breast cancer metastasis regulated at the level of RNA. One of the biggest surprises from genome sequencing projects is that nearly all human genes undergo alternative splicing. Inevitably, dysregulation of alternative splicing has been associated with hallmarks of cancer for over a decade. An outstanding question that remains is: Of the many alternative splicing events that occur in cancer, which events are the important drivers of carcinogenesis and metastasis? Recent work from our lab provided a conceptual understanding of RNA alternative splicing regulation in cancer processes, and we discovered a splicing-mediated pathway that drives breast cancer metastasis. Using the cancer stem cell marker CD44 as a model, we demonstrated that alternative splicing causally controls EMT and breast cancer progression. Manipulating the expression of specific CD44 splice isoforms or splicing factors that control CD44 alternative splicing disrupts EMT and metastasis. With support from our deep-sequencing data and breast cancer patient specimen analysis, these observations suggest critical therapeutic targets for preventing cancer cells from spreading. Together with our collaborators in basic science and clinical medicine, our ultimate goal is to bring our findings from the bench to the bedside for the treatment of metastatic cancers.[Shorten text]

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Education and Certification

  • MD: Peking University (1990)
  • PhD: Cornell U Medical Ca (2000)

Contact

Administrative office: 312-503-5248

Robert H Lurie Medical Research Center Room 5-119
303 E Superior
Chicago IL 60611