Northwestern University Feinberg School of Medicine
Department of Medicine

Focus of Work

Bio

Our laboratory utilizes DNA sequencing, gene expression profiling, proteomic analyses, flow cytometric methodology and many other basic techniques to pursue goals that are ultimately translatable for improving health and overall survival in patients with brain cancer. Although our research is primarily focused on malignant glioma, with a special emphasis on glioblastoma, we are also interested in pursuing incurable pediatric brain tumors, as well as metastatic tumors that invade the brain/spinal...[Read full text]Our laboratory utilizes DNA sequencing, gene expression profiling, proteomic analyses, flow cytometric methodology and many other basic techniques to pursue goals that are ultimately translatable for improving health and overall survival in patients with brain cancer. Although our research is primarily focused on malignant glioma, with a special emphasis on glioblastoma, we are also interested in pursuing incurable pediatric brain tumors, as well as metastatic tumors that invade the brain/spinal cord. It is our sincere hope that, the basic mechanistic investigations that we carry out, uncover important and meaningful discoveries that translate into highly effective immunotherapeutic modalities for the benefit of patients with incurable cancer in the brain.[Shorten text]

Academic Focus

The primary goal of our research is to analyze the immune response in human brain tumors, as well as syngeneic and humanized mouse brain tumor models, with the intent to develop and evaluate novel immunotherapeutic strategies for malignant brain cancer. We aim to: 1) discover new targets that increase immunosuppression, 2) develop new drugs that inhibit immunosuppression, 3) and test novel treatment strategies for clinical translation into human patients with malignant glioma.

Current Projects
...[Read full text]
The primary goal of our research is to analyze the immune response in human brain tumors, as well as syngeneic and humanized mouse brain tumor models, with the intent to develop and evaluate novel immunotherapeutic strategies for malignant brain cancer. We aim to: 1) discover new targets that increase immunosuppression, 2) develop new drugs that inhibit immunosuppression, 3) and test novel treatment strategies for clinical translation into human patients with malignant glioma.

Current Projects

-Dissect the multiple roles of immunosuppressive indoleamine 2,3 dioxygenase 1 (IDO) in glioblastoma (GBM)

-Determine how advanced age suppresses the effectiveness of immunotherapy for treatment of GBM

-Investigate the psychosocial aspects of stress, anxiety and/or depression on the suppression of immunotherapeutic efficacy for GBM.

-Characterize the gut microbiota of GBM patients, before and after treatment with immunotherapy[Shorten text]

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Education and Certification

  • MS: Loyola University-Chicago, Cell Biology, Neurobiology and Anatomy (2004)
  • PhD: Loyola University-Chicago, Cell Biology, Neurobiology and Anatomy (2009)
  • Postdoctoral Fellowship: University of Chicago, Surgery (2013)

Contact

Administrative office: 312-503-3161
Laboratory: 312-503-4345

Tarry Building Room 2-703
300 E Superior
Chicago IL 60611