Project 2: Pathogenic Mechanisms of CRS
Project 2 investigates the pathogenic mechanisms of chronic rhinosinusitis (CRS) in collaboration with Project 1 (GHS) and Project 3 (U of C) to test important hypotheses with clinical and potential therapeutic relevance in CRS.
The four overarching hypotheses are:
- that nasal polyp (NP) tissue promotes activation, proliferation and differentiation of B lineage cells leading to their expansion and autoimmune antibody production in the NP
- that autoimmunity is responsible for recalcitrant disease in patients that require frequent surgical intervention
- that exacerbations of CRS are triggered by human rhinovirus (HRV), explaining their predominance during the respiratory virus season
- that infection of CRS patients with HRV activates B lineage cells in patients with CRS
We are testing these hypotheses using laboratory investigations to understand observations made in humans and testing discoveries made in the laboratory in human subjects.