Read the latest news from Northwestern University Feinberg School of Medicine’s Department of Medicine, Division of Edocrinology, Metabolism, and Molecular Medicine. The links below take you to articles where you can learn more about our faculty’s latest achievements, awards, and honors.
If you’ve long struggled with your weight – or just recently put on some unexplained poundage – you’ve probably wondered about the health of your thyroid. After all, while more than 12 percent of Americans develop a thyroid condition in their lifetime, up to 60 percent of those sufferers are undiagnosed, according to the American Thyroid Association. And since the thyroid gland is in charge of producing T3 (triiodothyronine) and T4 (thyroxine), two hormones that, among other things, are in charge of setting your basal metabolic rate – the number of calories you burn every day just to stay alive – thyroid issues can easily trigger significant weight loss or, more commonly, weight gain, explains Dr. Peter A. Kopp, an endocrinologist at Northwestern Memorial Hospital in Chicago.
The time of day you hit the gym could have an impact on the quality of your workout, according to researchpublished in the October 2016 issue of Cell Metabolism.Researchers discovered circadian clocks in the muscle tissue that regulate how well it adapts to changes in the environment and activities throughout a 24-hour period. “Our sleep/wake cycle is programmed by our internal biological clock,” says lead researcher Joe Bass, MD, PhD, the chief of the Division of Endocrinology, Metabolism and Molecular Medicine at the Feinberg School of Medicine at Northwestern University. “There is a similar clock in the muscle tissue.”
Not So Sweet: Getting smart about sugar
Most of us are guilty of indulging in sugary foods and beverages over the holiday season. But with the new year, now is the time to get on track with your sugar intake. Knowing where to spot sugar is the first step. “The first thing that everybody needs to figure out is where the sugar is in their diet,” says Lisa Neff, MD, an endocrinologist at the Center for Lifestyle Medicine at Northwestern Memorial Hospital. Some sources of sugar are more obvious (think cookies, cake and ice cream), but others are well hidden.
The time of day determines a muscle's energy efficiency and metabolic response.
Northwestern Medicine scientists have discovered circadian clocks in muscle tissue that control the muscle's metabolic response and energy efficiency depending on the time of day. The finding in mice sheds light on the time-of-day differences in muscle's ability to adapt to exercise and use oxygen for energy. Muscle cells are more efficient during an organism's normal waking hours, the study found. All cells in the body, including those in muscle, contain a clock that regulates how cells adapt to changes in the environment and activity across the 24-hour day. "Oxygen and the internal clock are doing a dance together inside muscle cells to produce energy, and the time of day determines how well that dance is synchronized," said senior author Dr. Joseph Bass. "The capacity for a cell to perform its most important functions, to contract, will vary according to the time of day. More research is needed before the finding can be translated into workout advice.
Northwestern Medicine scientists have detected circadian clocks in flesh hankie that control a muscle’s metabolic response and appetite potency depending on a time of day. The anticipating in mice sheds light on a time-of-day differences in muscle’s ability to adjust to practice and use oxygen for energy. Muscle cells are some-more fit during an organism’s normal waking hours, a investigate found. All cells in a body, including those in muscle, enclose a time that regulates how cells adjust to changes in a sourroundings and activity opposite a 24-hour day. “Oxygen and a middle time are doing a dance together inside flesh cells to furnish energy, and a time of day determines how good that dance is synchronized,” pronounced comparison author Dr. Joseph Bass. “The ability for a dungeon to perform a many vicious functions, to contract, will change according to a time of day."
When Caster Semenya took to the 800-meter start line on Saturday, she did it in a uniform that was clearly different from those of her fellow Olympic competitors. She didn't wear cheeky briefs or a sleeveless top. Her green-and-yellow one piece extended from halfway to her knees to halfway to her elbows. Unlike those of the women lined up next to her, her abs were not exposed to the hot Rio air—or to the millions of spectators watching from around the world. Her body was under enough scrutiny already, with the world questioning if she was really a woman.
Thirty years of research translates into new treatment strategies for polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) afflicts over 14 million women in the United States. The disorder increases the risk of endometrial cancer, heart disease, high blood pressure, type 2 diabetes, asthma, obesity, depression and anxiety, as well as infertility and a variety of reproductive disorders. Despite its prevalence, no one has fully understood the origins of the syndrome nor has come up with any effective early treatment strategies for it — until now. Thanks to some long-time collaborating researchers in Wisconsin, Illinois and California — as well as their students, who have gone on to become better enlightened physicians and researchers themselves — the veil over understanding and treating PCOS is finally lifting.