The Division of Hematology and Oncology is focused on improving patients’ therapeutic options and quality of life while working to better prevent, diagnose and treat cancer and hematologic disorders.
“Our division houses laboratory-based investigators focused on a broad array of topics, including chemoprevention, cell signal pathways, epigenetics, immune-modulation, and nanotechnology theranostics.”
– William J. Gradishar, MD
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Faculty: Meet the Team
View individual profiles of our faculty members and learn about their research and clinical specialties.
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Associate Professor of Medicine (Hematology and Oncology) and Microbiology-Immunology
Cancer immunology and immunotherapy
Professor of Medicine (Hematology and Oncology)
I have been an active clinical investigator vested in the immune-based therapy of melanoma. This has led to my role in the clinical development of initially Interleukin-2 and more recently anti-CTLA-4 and anti-PD1/PDL-1. While checkpoint therapy has been a great breakthrough in cancer treatment, additional immune-based strategies are still critically needed. Efforts to identify mechanisms of resistance to checkpoint inhibitors and approaches to overcome de novo and acquired resistance are one of my major interest. In addition I have ongoing efforts in the personalized therapy of melanoma with ...
Professor of Medicine (Hematology and Oncology)
Myeloma, Transplantation
Professor of Medicine (Hematology and Oncology)
The overarching goal of my involvement in translational research is to improve the outcome of patients with lymphoma. With scientists in the US and abroad, we are currently investigating novel signaling pathways in lymphoma, using cell lines and animal model systems. More specifically, our research focuses on the biology of reactive oxygen species signaling pathways in lymphoma. Active investigations include: 1) the biology of the lactone diterpenoids in lymphoma; 2) the development of all trans retinoic acid (ATRA) and curcumin loaded nanodisks as a drug delivery vehicle in mantle cell lym...
Assistant Professor of Biochemistry and Molecular Genetics and Medicine (Hematology and Oncology)
The Ntziachristos laboratory studies the mechanistic aspects of oncogenesis with an emphasis on transcriptional and epigenetic regulation of acute leukemia. Up to 25% of children with Acute Lymphoblastic Leukemia will fail frontline therapy and their prognosis is dismal. Cure rates for patients relapsing on therapy are approximate 20%. While patients with later relapses have a better prognosis, the majority eventually succumbs to the disease (overall cure rate 40 to 50%). Important questions in our laboratory are related to how oncogenes interact with each other and with epigenetic modulator...
Professor of Medicine (Hematology and Oncology) and Biochemistry and Molecular Genetics
Research in the Crispino laboratory is focused on investigating the regulatory mechanisms governing normal and malignant blood cell development, with an emphasis on understanding the growth of erythroid cells (red blood cells) and megakaryocytes (platelet-producing cells). In addition, the group has a major interest in learning how changes in normal essential regulatory molecules lead to human blood diseases, including acute leukemias and myeloproliferative neoplasms (MPNs). The lab seeks to make seminal basic science discoveries while simultaneously translating these discoveries in ways that ...
Professor of Medicine (Hematology and Oncology) and Biochemistry and Molecular Genetics
The primary research focus of the lab is to understand aberrant transcriptional and epigenetic regulation of prostate cancer. We utilize high-throughput genomic techniques in combination with bioinformatics/statistical analysis to generate hypothetical concepts. We then test these hypotheses using traditional molecular or cellular biological approaches and examine the functional relevance of innovative mechanisms using in vitro cell line and in vivo mouse models. Transcription factors of particular interest to us include androgen receptor (AR), FoxA1, Polycomb group protein (EZH2), and the ...
Assistant Professor of Medicine (Hematology and Oncology)
My clinical interests include treating gastrointestinal malignancies. My research interests are on improving the quality of cancer care and better understanding the trends in use and expenditure of services and drugs. I am also interested in evaluation of cancer-related health policies.
Associate Professor of Medicine (Hematology and Oncology)
The diagnosis and treatment of bleeding disorders and their complications.
Evaluation of causes of thrombosis and education regarding treatment and prevention of thrombosis.
Assistant Professor of Medicine (Hematology and Oncology)
Interested in stem cell/bone marrow transplantation for malignant and non-malignant disorders, and patient outcomes after these transplants. Interested in cancer health disparities specifically in hematologic disorders. Interested in global health with improvement in outcomes for hematologic and oncologic conditions in all regions.
September 7
8:00 AM - 9:00 AM
September 14
8:00 AM - 9:00 AM
September 15
12:30 PM - 3:30 PM
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Learn MoreDiversity and Inclusion
The department works toward an environment of inclusion and support through the Diversity and Cultural Affairs Council and through several dedicated events and initiatives.
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Housestaff Research Portal
Graduate Research Resources
We offer a wide range of resources, mentorship opportunities and training to help our residents and fellows excel as physician-scientists. Explore all of the resources and hear from housestaff who are making research a major part of their career development plans.
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Contact Terri Dillon for more information on supporting the Division of Hematology-Oncology at 312-503-4837 or terri-dillon@northwestern.edu.
