The Division of Nephrology has 18 full-time faculty members based at Northwestern University who are actively engaged in research activities spanning over the Chicago and Evanston campuses. In addition, the division has close ties and shared training with the Department of Pediatrics, Division of Nephrology at Ann & Robert H. Lurie Children’s Hospital of Chicago.
Basic and Translational Research
Our newly renovated state of the art research facility boasts research space that comprise activities ranging from bench to bedside. We focus on collaborative research within other divisions and centers at Feinberg.
Center for Translational Metabolism and Health
The Center for Translational Metabolism and Health, housed in the Institute for Public Health and Medicine, unites Feinberg scientists from across multiple disciplines to explore the role of nutrition in health and disease. Directed by division faculty member Tamara Isakova, MD, MMSc the CTMH hypothesizes that that large amounts of phosphate-based additives, consumed through processed foods, contribute to heart failure (HF) and advanced chronic kidney disease (CKD). Learn more about their work via the CTMH website.
Center for Kidney Research and Therapeutics
The Center for Kidney Research and Therapeutics is housed in the Feinberg Cardiovascular Research Institute. Director Xunrong Luo, MD, PhD's goal is to utilize a partnership between innovative researchers, dedicated physicians and committed patients to develop a pipeline of cutting-edge and personalized therapeutics for kidney diseases, and for comorbidities developed as a consequence of reduced kidney function and/or dialysis treatments.
Our clinical research programs are active and growing rapidly. We are currently involved in four clinical trials. Our transplant nephrologists (M. Javeed Ansari, MD; John Friedewald, MD; Lorenzo Gallon, MD; Xunrong Luo, MD, PhD) are actively involved in clinical transplantation research, particularly in the area of tolerance, in collaboration with faculty members in the Departments of Surgery and Microbiology-Immunology.
Seeking an understanding of the mechanisms of transplant rejection and tolerance using animal models and clinical material.
Focusing on the renin angiotensin system as it relates to the understanding of human diabetic kidney disease and rodent models of diabetic kidney disease and hypertension
Molecular mechanisms of metabolic bone diseases, with particular emphasis on the regulation and function of FGF23 in situations of normal and abnormal mineral metabolism.
Studying ion channel relevance in cell biology and disease progression
Looking to improve outcomes in renal transplantation.
Specializing in disordered mineral metabolism in chronic kidney disease; supporting a multi-center study testing the biochemical efficacy and safety of phospates and FGF-23-lowering interventions in patients with stage 3-4 chronic kidney disease.
Seeking to understand the molecular mechanisms of kidney and vasculature diseases.
The Lin lab studies the functional significance of human-based genomic and transcriptomic discoveries in cardiometabolic and kidney diseases.
The Martin Lab investigates the role of the skeleton in the endocrine regulation of mineral metabolism and the cardiovascular complications of mineral and bone diseases.
Investigating disordered phosphate homeostasis and the pathogenesis of microvascular disease in chronic kidney disease.
Exploring how each specific cell type and organ acquires all its specific and unique morphological and functional characteristics during embryogenesis
Uncovering the molecular mechanisms of diabetic vascular complications, thrombotic microangiopathy, glomerular diseases and glaucoma
Investigating novel markers of chronic kidney disease and acute kidney injury to identify and evaluate better methods to phenotype kidney diseases.