Skip to main content

Division of Hematology & Oncology

headshot of Dr. Munshi, division chief

Our division, one of the largest in the Department of Medicine, is committed to providing exceptional clinical care, conducting transformative translational and clinical research, and teaching and mentoring our trainees and junior faculty.”

Hidayatullah G. Munshi, MD
Chief, Division of Hematology & Oncology

About Our Division

The Division of Hematology & Oncology at Northwestern University Feinberg School of Medicine is dedicated to advancing the prevention, diagnosis and treatment of cancer and hematologic disorders. Our team of over 58 faculty members delivers cutting-edge, compassionate care to thousands of patients annually in state-of-the-art facilities.

Through innovative research programs such as the Northwestern Medicine Developmental Therapeutics Institute and OncoSET, we pioneer novel therapies and personalized medicine approaches. We also train future leaders in hematology and oncology through comprehensive fellowship programs. By integrating patient care, research and education, we continually strive to improve patient outcomes and drive scientific discovery in our field.

Education

The Hematology & Medical Oncology Fellowship trains and mentors academic leaders in medical oncology and hematology. Seven fellows are selected annually and receive three-year stipends. The purpose of the program is to expose fellows to the clinical practice of hematology and oncology. The program is education-oriented, includes patient care and leads to board eligibility in Medical Oncology and Hematology.

Explore our fellowship program

Research

The Division of Hematology & Oncology is a community of scientific colleagues who are very active members of our NCI-designated Robert H. Lurie Comprehensive Cancer Center of Northwestern University. Our faculty conduct clinical studies and basic science and translational research that encompass many subspecialties of hematology and oncology. We have 58 full-time faculty members and nine labs that are actively performing over $10.2 million each year in grant-funded research. To learn more, view our clincial trials or read our latest publications.

Discover the connections between our division and many of the innovative research centers throughout Northwestern Medicine:

Training Program in Signal Transduction & Cancer

The Training Program in Signal Transduction & Cancer enables four postdoctoral fellows per year to receive state-of-the-art training in signal transduction pathways and the role of aberrant signaling pathways in human cancer. Trainees receive two years of funding to conduct research to investigate the mechanism by which cytokines, growth factors and receptors control cell fate, transformation, metastasis and cell growth.

Learn more about this program

Learn more about the exceptional work of our division's research laboratories below.

Elizabeth Eklund Lab

The Eklund Lab, let by Elizabeth Eklund, MD, is working to understand the molecular events that lead to development of myeloid leukemias (acute myeloid leukemia and chronic myeloid leukemia) and to the evolution of drug resistance in these diseases. The goal is to identify potential molecular therapeutic targets that would delay or prevent drug resistance and relapse in AML and CML. In related projects, the laboratory is investigating Fanconi Anemia, a genetic disease with defective DNA repair. Patients with Fanconi Anemia frequently develop leukemia and provide a model for understanding the role of DNA repair in leukemogenesis.

Publications

View lab publications via PubMed.

For more information, visit Eklund's faculty profile.

Contact Us

Contact Eklund at 312-503-3208 or the lab at 312-503-3208.

Hau Kwaan Lab

The Kwaan Lab has blood samples from patients diagnosed with acute promyelocytic leukemia and myeloproliferative neoplasms. Using different methodologies, Hau Kwaan, MD, PhD, is examining the cellular origins of the microparticles present in the plasma. He is also interested in the thrombotic  potential of these microparticles. The lab already found that tissue factor are carried by these microparticles. The microparticles also carry members of the plasmin, plasminogen system. These microparticles are increased in these two prothrombotic disorders. In addition, the lab also studies the amount of thrombin generated by these microparticles. These were found to be abnormally high during active phase of acute promyelocytic leukemia with return to normal after treatment.

Presently, Hwaan is working with a fellow looking at if there is a correlation in the number of reticulated platelets present in patients diagnosed with conditions associated with high platelet turnorver, including essential thrombocytopenia, disseminated intravascular coagulation, idiopathic thrombocytopenic purpura and thrombotic thrombocytopenic purpura.

Publications

View lab publications via PubMed.

For more information, visit Kwaan's faculty profile.

Contact Us

Contact Kwaan at 312-695-6180 or the lab at 312-503-1356.

 

Adam Lin Lab

The Lin Lab focuses on lymphoma, cellular therapies, and stem cell transplantation. Our lab, the Nanotechnology and Biomaterials Lab for Blood Cancers, aims to bridge the gap between technological advancements and their use in clinical or personalized medicine to provide new treatment options for patients with hematologic malignancies; "Find the right technology for the right patient."

 For more information, visit Lin's faculty profile.

Contact Us

Adam Y Lin, MD,PhD
676 North Saint Clair St., Arkes 850, Chicago, IL 60611
adam.lin@northwestern.edu

Hidayatullah G. Munshi Lab

The Munshi Lab is focused on understanding the role of the key collagenase MT1-MMP (MMP-14) and members of the Snail family transcription factors in pancreatic cancer progression using transgenic mouse models. We are also interested in understanding how the pronounced fibrotic reaction induces epigenetic changes to contribute to chemotherapy resistance. We have shown that the collagen microenvironment induces histone acetylation and that targeting 'readers' of histone acetylation marks using BET inhibitors can limit growth of pancreatic cancer cells. We plan to evaluate the efficacy of BET inhibitors in our mouse models with the eventual goal of testing this class of inhibitors in patients with pancreatic cancer.

Publications

View lab publications via PubMed.

For more information, visit the faculty profile page of Hidayatullah G Munshi, MD.

Contact Us

Contact Hidayatullah Munshi, MD, at 312-695-6180 or the Munshi Lab at 312-503-0312.

Leonidas Platanias Lab

Cell signaling is part of an intricate system of events activated by various stimuli that coordinate cell responses. Our laboratory is interested in unveiling pathways involved in cancer development in order to target them and control cancer progression. For over two decades, the Platanias Laboratory has identified several cellular cascades activated by IFN, ATRA and arsenic.

Our research on Type I IFN found an essential role for SKAR protein in the regulation of mRNA translation of IFN-sensitive genes and induction of IFN-α biological responses. We also provided evidence for unique function of mTORC2 complex in inducing Type I IFN response. Our studies on arsenic signaling revealed a direct binding of this compound to a kinase called AMPK as a mechanism underlying its anti-leukemic activity. Other work included the activation of biological responses by BCR-ABL oncoprotein through the mTOR pathway.

The Platanias Laboratory — led by Leonidas Platanias, MD, PhD — is also involved in testing new compounds in combination with approved therapies in order to identify synergy and improve the risk/benefit ratios of current therapeutic regimens for patients.

For more information, visit Platanias' faculty profile.

Publications

View lab publications via PubMed.

Contact

Contact Platanias at 312-908-5250 or the lab at 312-503-4500.

Marcus Peter Lab

The Peter Lab studies various forms of cell death including apoptosis, which is a fundamental process to regulate homeostasis of all tissues and to eliminate unwanted cells specifically in the immune system. Another interest lies in the study of RNA interference and based on toxic RNAs to development a novel form of cancer treatment. 

For more information, visit the laboratory's website.

Jindan Yu Lab

The Yu Lab — led by Jindan Yu, MD, PhD — focuses on cancer genomics and translational cancer research. At the current stage, our primary research interest is to understand aberrant transcriptional and epigenetic regulation of prostate cancer and to translate such knowledge into clinical applications. We utilize high-throughput genomic techniques in combination with bioinformatics/statistical analysis to generate testable hypothesis. We then test these hypotheses using traditional molecular and/or cellular biological approaches and examine the functional relevance of these innovative regulatory pathways in vitro and in vivo using cell lines and mouse models.  Based on the genetic and epigenetic underpinning of the disease, we pursue translational research to develop new biomarkers and novel therapeutics strategies for advanced prostate cancer.

View all lab publications via PubMed.

For more information, visit Yu's faculty profile.

Contact Us

Contact Yu at 312-503-2980 or the lab at 312-503-3041.

Bin Zhang Lab

The Zhang Lab is focused on understanding the mechanisms of tumor-induced immune evasion. The overall goal is to develop novel and feasible strategies to improve cancer immunotherapy. Principal investigator Bin Zhang, MD, PhD, has been recently interested in the tumor microenvironment complexity whereby CD73 functions as an ecto-enzyme to produce extracellular adenosine, which limits anti-tumor T cell immunity. He is exploring the detailed mechanisms of CD73 by which the tumors evade the immune system using a combination of molecular, biochemical and mouse genetic approaches and to accomplish the targeted elimination of CD73 as a novel means to enhance cancer immunotherapy.

Other ongoing studies are working to:

  • Analyze the contribution of new key molecules including microRNAs from the perspective of cancer immunology in regulating regulatory T cells and/or myeloid derived suppressive cells
  • Define a novel use of pre-existing chemotherapy drugs to overcome tumor-mediated immunosuppression
  • Characterize the role of novel molecules in tumor T cell immunity and autoimmunity
  • Understand the differential immune regulation in GVHD vs. GVL
  • Develop new animal models that can be employed in preclinical studies to most reflect human clinical trials.

Publications

View lab publications via PubMed.

For more information, visit Zhang's faculty profile.

Contact Us

Contact Zhang at 312-695-6180 or the lab at 312-503-2435.

Contact Us

We welcome your questions and comments at the Division of Hematology & Oncology at Northwestern University Feinberg School of Medicine. Please contact our division office via the information below.

Lurie Medical Research Center
303 E. Superior St., Floor 5
Chicago, IL 60611
Phone: 312-503-1114
Fax: 312-503-0189

Arkes Pavilion
676 N. Saint Clair St., Suite 850
Chicago, IL 60611
Phone: 312-695-6180
Fax: 312-695-6189

Patients seeking appointments, please call 312-695-0990.

Division Administrator
Christine Miller
christine.miller@northwestern.edu

Giving

We invite your philanthropic partnership in helping us achieve our research and teaching missions each day. Contact Terri Dillon for more information on supporting the Division of Hematology & Oncology at 312-503-4837 or terri-dillon@northwestern.edu.

Make an Online Donation